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ALKALINE PHOSPHATASE ACTIVITY IN THE BONES OF NORMAL AND SCORBUTIC GUINEA PIGS : A CORRELATED BIOCHEMICAL AND HISTOCHEMICAL STUDY

ANITA ZORZOLI 1 and E. M. NADEL 1

1 Southern Illinois University, Carbondale, Illinois and National Cancer Institute, Bethesda, Maryland

Alkaline phosphatase activity was measured in the tibias of normal and scorbutic guinea pigs. After twenty six days on a scorbutogenic diet the activity in the scorbutic had a mean value of 4.16 mg P/gm/hour in comparison to 8.04 mg P/gm/hour for the control group. Histochemical study of sections of the bones after demineralization revealed a decrease in the black precipitate indicative of phosphatase activity in the scorbutic bones. The decrease in precipitate was especially striking in the epiphyseal plate and in the metaphysis.

Submitted on June 10, 1953


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 Arch DermatolHome page
A. W. KOPF
The Distribution of Alkaline Phosphatase in Normal and Pathologic Human Skin
Arch Dermatol, January 1, 1957; 75(1): 1 - 37.
[Abstract] [PDF]



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