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HISTOCHEMICAL DEMONSTRATION OF NOREPINEPHRINE AT A FINE STRUCTURAL LEVEL

JOE G. WOOD 1 and RUSSELL J. BARRNETT 1

1 Department of Anatomy, Yale University School of Medicine, 333 Cedar Street, New Haven 11, Connecticut

The present work describes a method for the histochemical demonstration of, and the differentiation between, norepinephrine and epinephrine at a fine structural level in cells of the adrenal medulla. The two catecholamines are definitely contained in granules which occur in two different cell types; one for norepinephrine, the other for epinephrine. No evidence could be adduced from the present material that norepinephrine material served as a precursor for epinephrine granules. Preliminary observations are included on the occurence of catecholamine-containing granules in neuronal processes of the hypothalamus.

Submitted on July 8, 1963


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F. E. Bloom and G. K. Aghajanian
Cytochemistry of Synapses: Selective Staining for Electron Microscopy
Science, December 23, 1966; 154(3756): 1575 - 1577.
[Abstract] [PDF]



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