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MICROSCOPIC IMMUNOFLUORESCENCE OF GLOMERULI IN CHRONIC NEPHROTOXIC SERUM NEPHRITIS

J. H. BOSS 1

1 Departments of Pathology, University of Pittsburgh School of Medicine, and the Magee-Women's Hospital, Pittsburgh, Pa.

The microscopic immunofluorescence of the glomeruli differs in acute and chronic nephrotoxic serum nephritis in the distribution pattern of the injected nephrotoxic globulin and the host's gamma globulin. In acute nephritis specific glomerular fluorescence, denoting fixation of nephrotoxic and recipient's gamma globulin, is sharply limited to regular, thin and delicate lines corresponding to the capillary basement membranes. On the other hand, specific glomerular fluorescence in chronic nephritis appears as irregular, broad and tortuous loops consisting of coarse, partially coalescing specks of differing brightness. This difference is possibly related to the profound alterations in chronic nephritis resulting in reconstruction of the glomerular architecture.

Submitted on November 30, 1964


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