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THE DEMONSTRATION OF ACID HYDROLASE ACTIVITIES IN THE INCLUSION BODIES OF TYPE II ALVEOLAR CELLS AND OTHER LYSOSOMES IN THE RABBIT LUNG

SIDNEY GOLDFISCHER 1, YUTAKA KIKKAWA 1, and LEE HOFFMAN 1

1 Departments of Pathology and Medicine, Albert Einstein College of Medicine, Bronx, New York

Type II alveolar epithelial cells show high levels of acid phosphatase, aryl sulfatase B and beta-glucuronidase activities. In formalin- and glutaraldehyde-fixed rabbit lung acid phosphatase and aryl sulfatase B activities were demonstrated in the cytoplasmic inclusion bodies, supporting their identification as lysosomes. Type II cells differ from alveolar macrophages in their levels of hydrolase activity and the fine structure of their active sites.

Submitted on October 2, 1967


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