|
|
|
|
 |
|||
|
|||
THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT
1 Royal postgraduate Medical School, London, England
A group of apparently unrelated endocrine cells, some in endocrine glands, others in nonendocrine tissues, share a number of cytochemical and ultrastructural characteristics. These characteristics, from the initial letters of four of which the term APUD is derived, indicate the possession of a common metabolic pattern and common synthetic, storage and secretion mechanisms. It is postulated that the various characteristics reflect the production and storage of hormone precursor protein which has a predominantly random coil conformation. Several explanations are possible to account for the APUD characteristics but if the cells, in fact, share a common ancestor the only possible candidate is the neural crest cell.
Submitted on January 2, 1969
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. H. Coolidge, C. S. Ciuhandu, and W. K. Milsom A comparative analysis of putative oxygen-sensing cells in the fish gill J. Exp. Biol., April 15, 2008; 211(8): 1231 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J.L.M. Timmers, M. Hadi, J. A. Carrasquillo, C. C. Chen, L. Martiniova, M. Whatley, A. Ling, G. Eisenhofer, K. T. Adams, and K. Pacak The Effects of Carbidopa on Uptake of 6-18F-Fluoro-L-DOPA in PET of Pheochromocytoma and Extraadrenal Abdominal Paraganglioma J. Nucl. Med., October 1, 2007; 48(10): 1599 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Asamura, T. Kameya, Y. Matsuno, M. Noguchi, H. Tada, Y. Ishikawa, T. Yokose, S.-X. Jiang, T. Inoue, K. Nakagawa, et al. Neuroendocrine Neoplasms of the Lung: A Prognostic Spectrum J. Clin. Oncol., January 1, 2006; 24(1): 70 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Orlefors, A. Sundin, U. Garske, C. Juhlin, K. Oberg, B. Skogseid, B. Langstrom, M. Bergstrom, and B. Eriksson Whole-Body 11C-5-Hydroxytryptophan Positron Emission Tomography as a Universal Imaging Technique for Neuroendocrine Tumors: Comparison with Somatostatin Receptor Scintigraphy and Computed Tomography J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3392 - 3400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Becherer, M. Szabo, G. Karanikas, P. Wunderbaldinger, P. Angelberger, M. Raderer, A. Kurtaran, R. Dudczak, and K. Kletter Imaging of Advanced Neuroendocrine Tumors with 18F-FDOPA PET J. Nucl. Med., July 1, 2004; 45(7): 1161 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hoegerle, C. Altehoefer, N. Ghanem, G. Koehler, C. F. Waller, H. Scheruebl, E. Moser, and E. Nitzsche Whole-Body 18F Dopa PET for Detection of Gastrolintestinal Carcinoid Tumors Radiology, August 1, 2001; 220(2): 373 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Cooper, V. H. Thourani, A. A. Gal, R. B. Lee, K. A. Mansour, and J. I. Miller The Surgical Spectrum of Pulmonary Neuroendocrine Neoplasms Chest, January 1, 2001; 119(1): 14 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Remadi, W. MacGee, E. Megevand, P. Chappuis, M. Redard, and T. A. Seemayer Resident Neuroendocrine Cells in the Normal Ectoendocervical Epithelium: An Immunohistochemical Study of 1 00 Cases Using a Microwave Heating Technique International Journal of Surgical Pathology, July 1, 1997; 5(1-2): 19 - 23. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Kobayashi, S. Morita, H. Sawada, T. Mizuguchi, K. Yamada, I. Nagatsu, T. Hata, Y. Watanabe, K. Fujita, and T. Nagatsu Targeted Disruption of the Tyrosine Hydroxylase Locus Results in Severe Catecholamine Depletion and Perinatal Lethality in Mice J. Biol. Chem., November 10, 1995; 270(45): 27235 - 27243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Craig, F. A. Carey, W. S. Walker, and E. W. J. Cameron Primary small-cell cancer of the esophagus J. Thorac. Cardiovasc. Surg., February 1, 1995; 109(2): 284 - 288. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Greaves Differentiation-linked leukemogenesis in lymphocytes Science, November 7, 1986; 234(4777): 697 - 704. [Abstract] [PDF]
|
|
|
|
|
|
A. Gazdar, P. Bunn Jr, J. Minna, and S. Baylin Origin of human small cell lung cancer Science, August 16, 1985; 229(4714): 679 - 680. [PDF]
|
|
|
|
|
|
R. Lloyd and B. Wilson Specific endocrine tissue marker defined by a monoclonal antibody Science, November 11, 1983; 222(4624): 628 - 630. [Abstract] [PDF]
|
|
|
|
|
|
S. Baylin, S. Hsu, D. Gann, R. Smallridge, and S. Wells Jr Inherited medullary thyroid carcinoma: a final monoclonal mutation in one of multiple clones of susceptible cells Science, January 27, 1978; 199(4327): 429 - 431. [Abstract] [PDF]
|
|
|
|
|
|
S. Baylin, D. Gann, and S. Hsu Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma Science, July 23, 1976; 193(4250): 321 - 323. [Abstract] [PDF]
|
|
|
|
|
|
R. Pictet, L. Rall, P Phelps, and W. Rutter The neural crest and the origin of the insulin-producing and other gastrointestinal hormone-producing cells Science, January 16, 1976; 191(4223): 191 - 192. [Abstract] [PDF]
|
|
|
|
|
|
S. Hoegerle, E. Nitzsche, C. Altehoefer, N. Ghanem, T. Manz, I. Brink, M. Reincke, E. Moser, and H. P. H. Neumann Pheochromocytomas: Detection with 18F DOPA Whole-Body PET3Initial Results Radiology, February 1, 2002; 222(2): 507 - 512. [Abstract] [Full Text] [PDF]
|
|
| Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact |