Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BRECKENRIDGE, B. McL.
Right arrow Articles by JOHNSTON, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BRECKENRIDGE, B. McL.
Right arrow Articles by JOHNSTON, R. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE IN BRAIN

BRUCE McL. BRECKENRIDGE 1 and ROBERT E. JOHNSTON 1

1 Department of Pharmacology, Rutgers Medical School, New Brunswick, New Jersey 08903

The distribution of cyclic 3',5'-nucleotide phosphodiesterase activity in the rabbit central nervous system has been studied with a quantitative micromethod. A wide range of values between various structures was observed, but correlations with cellular density, monoamine content or other enzymes were not apparent. Phosphodiesterase activity is not uniquely associated with particular layers of the cerebral cortex or with specialized synaptic structures in the olfactory bulb. The enzyme level was unaltered in the rat superior cervical ganglion after section of preganglionic fibers, and in the cerebral cortex after lesion of the medial forebrain bundle. Major disparities in comparing these results with those of a Gomori type procedure may be explained in part by the inhibition of the enzyme by lead ion.

Submitted on April 8, 1969


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 ScienceHome page
M Zatz and R. O'Dea
Efflux of cyclic nucleotides from rat pineal: release of guanosine 3',5'-monophosphate from sympathetic nerve endings
Science, July 8, 1977; 197(4299): 174 - 176.
[Abstract] [PDF]

Home page
 ScienceHome page
B. Beer, M. Chasin, D. E. Clody, J. R. Vogel, and Z. P. Horovitz
Cyclic Adenosine Monophosphate Phosphodiesterase in Brain: Effect on Anxiety
Science, April 28, 1972; 176(4033): 428 - 430.
[Abstract] [PDF]

Home page
 ScienceHome page
R. G. Pannbacker, D. E. Fleischman, and D. W. Reed
Cyclic Nucleotide Phosphodiesterase: High Activity in a Mammalian Photoreceptor
Science, February 18, 1972; 175(4023): 757 - 758.
[Abstract] [PDF]

Home page
 ScienceHome page
N. T. Florendo, R. J. Barrnett, and P. Greengard
Cyclic 3',5'-Nucleotide Phosphodiesterase: Cytochemical Localization in Cerebral Cortex
Science, August 20, 1971; 173(3998): 745 - 747.
[Abstract] [PDF]

Home page
 ScienceHome page
D. A. McAfee, M. Schorderet, and P. Greengard
Adenosine 3',5'-Monophosphate in Nervous Tissue: Increase Associated with Synaptic Transmission
Science, March 19, 1971; 171(3976): 1156 - 1158.
[Abstract] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 1969