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THE EFFECT OF COMA ON THE ENZYMES OF THE BRAIN: HISTOCHEMICAL AND BIOCHEMICAL STUDY

RICHARD D. CHESSICK 1

1 From the Department of Medicine, University of Chicago, Chicago 37, Illinois

Histochemical and quantitative chemical evidence is presented that coma induced by pentobarbital, insulin, or anoxia does not affect the distribution of concentration of acid phosphatase, alkaline phosphatase, phosphamidase, 5-nucleotidase, agr-naphthol esterase and naphthol AS esterase in the brain of the rat. Soulairac's findings that the alkaline phosphatase activity is markedly decreased in coma have not been confirmed. The interpretation of Swank and Cammermeyer's reported shift in the acid phosphatase concentration is open to doubt.

Submitted on November 12, 1953


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