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EVALUATION OF CORRELATIONAL INFORMATION IN DIGITIZED CELL IMAGES

WAYBURN S. JETER 1, GEORGE B. OLSON 1, PETER H. BARTELS 2, GUNTER F. BAHR 3, JOHN TAYLOR JR. 4, and GEORGE L. WIED 4

1 Departments of Microbiology, University of Arizona, Tucson, Arizona 85721
2 Departments of Microbiology and the Optical Sciences Center, University of Arizona, Tucson, Arizona 85721
3 Biophysics Branch, Armed Forces Institute of Pathology, Washington, D.C., 20012
4 Departments of Obstetrics and Gynecology and of Pathology, University of Chicago, Chicago, Illinois 60637

The processing of digitized cell images by computer may yield information not only about a set of cell image properties but also about their mutual dependencies. Observation of the covariance matrix of image properties of cellular material showing a response to chemotherapeutic treatment, ionizing radiation or antigenic challenge or following a developmental trend may permit a quantitative description of small trendal charges The covariance between certain cell image properties may show statistically significant changes before the mean values of the image properties are affected. Methods of reducing the dimensionality of the representation in an efficient manner are described.

Submitted on May 18, 1973


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