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AUTOMATIC RECOGNITION OF IRRADIATED CHROMOSOMES

RAJ K. AGGARWAL 1 and K. S. FU 1

1 School of Electrical Engineering, Purdue University, West Lafayette, Indiana 47907

There are essentially three types of aberrations of irradiated chromosomes in a mitotic cell; namely, fragments, rings and dicentrics, which are resulted from breakages and exchanges of chromatids. The occurrence of any of these aberrations is considered to be a very useful indicator of radiation damage at cell level. The large volume of tests required for monitoring health-related radiation damage necessitates an automated system for recognition of these aberrant chromosomes. Such a system, using a cutoff level independent skeletonization approach, has been developed and is discussed in this paper. The test results on 15 abnormal cells are also presented.

Submitted on January 30, 1974


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