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TECHNIQUES APPLICABLE TO COMPUTER-AIDED CYTOPHOTOMETRY IN VIROLOGY

VOLKER TER MEULEN 1, KLAUS KOSCHEL 1, HANS M. AUS 2, MATHILDA KAEKELL 3, and WOLFGANG SCHOLZ 4

1 Institute of Virology, University of Würzburg, Würzburg, West Germany
2 Max-Planck-Institute for Biophysical Chemistry, University of Göttingen Medical Center, Göttingen, Germany
3 Department of Pediatrics, University of Göttingen Medical Center, Göttingen, Germany
4 Department of Neuropathology, University of Göttingen Medical Center, Göttingen, Germany

Computer-aided cytophotometry is a new tool in the analysis of virus-infected cells. Structural changes of the cell morphology can easily be recognized and interpreted by the analytic systems available. More specific biochemical events that occur during virus replication can in certain instances be recorded and recognized if well defined trace markers are applied. This is demonstrated on poliomyelitis virus-infected HeLa cells.

Submitted on January 31, 1974


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