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Ultrastructural immunoenzymatic study of alpha-fetoprotein-producing cells in the human fetal liver

S Peyrol, JA Grimaud, Y Pirson, JA Chayvialle, C Touillon and B Lambert

Cells producing alpha-fetoprotein in human fetal liver have been studied with specific horseradish peroxidase labeled immunoglobulins. Under light microscopy, the alpha-fetoprotein is strictly localized in the cytoplasm of certain hepatocytes, distributed randomly in the hepatic lobule. Ultrastructural examination of thesame cells shows that the alpha-fetoprotein is present within the cytoplasm. Ultrastructural differences are described in hepatocytes according to whether or not the cell is producing alpha-fetoprotein at the time of sampling. These observations lead to the hypothesis that alpha-fetoprotein may correspond to a particular functional state of the hepatocyte in human fetal liver.

Volume 25, Issue 6, pp. 432-438, 06/01/1977
Copyright © 1977 by The Histochemical Society


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 Obstet GynecolHome page
J. L. BARTHA, R. ROMERO-CARMONA, R. COMINO-DELGADO, F. ARCE, and J. ARRABAL
Alpha-Fetoprotein and Hematopoietic Growth Factors in Amniotic Fluid
Obstet. Gynecol., October 1, 2000; 96(4): 588 - 592.
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