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Morphometry of the effect of increased experience and training on synaptic density in area CA3 of the rat hippocampus

RA Altschuler

A morphometric analysis of the effect of differential experiences on synapses was performed in area CA3 of the rat hippocampus. Two methods of quantitation that used a superimposed lattice grid were employed. In the first method squares overlying synapses were measured as a proportion of the total number of squares scanned; in the second method intersections of lattice lines with synapses were counted as a proportion of the total length of lines. Both measures showed that rats which were housed in an enriched environment and received 10 weeks of training had a significant increase in total area of synaptic contacts compared to both nonenriched controls and a croup with increased motor activity.

Volume 27, Issue 11, pp. 1548-1550, 11/01/1979
Copyright © 1979 by The Histochemical Society


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