Innervation of the pancreas by substance P, enkephalin, vasoactive intestinal polypeptide and gastrin/CCK immunoractive nervesLI Larsson
Immunocytochemical studies habe shown that many peptides which profoundly affect the endocrine and exocrine functions of the pancreas are localized to neurons. In the cat, such peptidergic nerves appear to innervate ganglia, islets and blood vessels of the pancreas, whereas their contributions to exocrine cells are minor. Our studies suggest that pancreatic ganglia represent one major site of action of the peptides and that, in addition, nerves containing the vasoactive intestinal polypeptide and gastrin/CCK-related peptides profoundly affect pancreatic blood flow and insulin secretion, respectively.
Volume 27,
Issue 9,
pp. 1283-1284,
09/01/1979
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K. Shimizu, Y. Kato, K. Shiratori, Y. Ding, Y. Song, R. Furlanetto, T.-M. Chang, S. Watanabe, N. Hayashi, M. Kobayashi, et al. Evidence for the Existence of CCK-Producing Cells in Rat Pancreatic Islets Endocrinology, January 1, 1998; 139(1): 389 - 396. [Abstract] [Full Text] [PDF] |
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