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Morphologic probes of polypeptide hormone receptor interactions

P Gorden, JL Carpentier, P Freychet and L Orci

Polypeptide hormones, growth factors, and a variety of other naturally occurring ligands bind specifically to receptors on the cell surface. At physiologic temperatures these ligands are internalized by cells and associate intracellularly with lysosomes. Receptor-mediated internalization provides a simple mechanism that may act to couple receptor-mediated hormone degradation with receptor-medicated receptor regulation.

Volume 28, Issue 8, pp. 811-817, 08/01/1980
Copyright © 1980 by The Histochemical Society


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Y. Patel, M Amherdt, and L Orci
Quantitative electron microscopic autoradiography of insulin, glucagon, and somatostatin binding sites on islets
Science, September 17, 1982; 217(4565): 1155 - 1156.
[Abstract] [PDF]




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