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Development of the heterogeneous distribution of carbamoyl-phosphate synthetase (ammonia) in rat-liver parenchyma during postnatal development
JW Gaasbeek Janzen, AF Moorman, WH Lamers and R Charles
Carbamoyl-phosphate synthetase (ammonia) is homogeneously distributed in rat-liver parenchyma at birth, as demonstrated by immunohistochemistry. A heterogeneous distribution can first be demonstrated at 6 days post partum, but can be masked by use of a too sensitive detection system. This heterogeneity is established by a decrease in enzyme content around the hepatic venules and a considerable increase in enzyme content in the remaining parenchyma. The perivenous decrease in enzyme content does not occur in all hepatocytes synchronously. The adult type of heterogeneity is characterized by a perivenous layer, only two to three cells thick, in which carbamoyl-phosphate synthetase can no longer be detected, irrespective of the sensitivity of the assay used. This situation is fully established at the age of two months.
Volume 33,
Issue 12,
pp. 1205-1211,
12/01/1985
Copyright © 1985 by The Histochemical Society
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  R. Notenboom, P. de Boer, A. Moorman, and W. Lamers The establishment of the hepatic architecture is a prerequisite for the development of a lobular pattern of gene expression Development, January 1, 1996; 122(1): 321 - 332. [Abstract] [PDF]
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