Synthesis of transthyretin (pre-albumin) mRNA in choroid plexus epithelial cells, localized by in situ hybridization in rat brainAJ Stauder, PW Dickson, AR Aldred, G Schreiber, FA Mendelsohn and P Hudson
The sites of synthesis of transthyretin in the brain were investigated using in situ hybridization with [35S]-labeled recombinant cDNA probes specific for transthyretin mRNA. Autoradiography of hybridized coronal sections of rat brain revealed specific cellular localization of transthyretin mRNA in choroid plexus epithelial cells of the lateral, third, and fourth ventricles. Transferrin mRNA was also investigated and, in contrast to transthyretin mRNA, was localized mainly in the lateral ventricles. Our results indicate that substantial synthesis of transthyretin and transferrin mRNA may occur in the choroid plexus.
Volume 34,
Issue 7,
pp. 949-952,
07/01/1986
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S. J. Richardson, J. A. Monk, C. A. Shepherdley, L. O. E. Ebbesson, F. Sin, D. M. Power, P. B. Frappell, J. Kohrle, and M. B. Renfree Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1264 - R1272. [Abstract] [Full Text] [PDF] |
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A. Quintas, D. C. Vaz, I. Cardoso, M. J. M. Saraiva, and R. M. M. Brito Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants J. Biol. Chem., July 13, 2001; 276(29): 27207 - 27213. [Abstract] [Full Text] [PDF] |
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