|
|
|
|
 |
|||
|
|||
Changes in the glycosylation pattern during embryonic development of mouse kidney as revealed with lectin conjugates
L Laitinen, I Virtanen and L Saxen
Distribution of lectin-binding sites in adult and developing mouse kidney was studied with fluorochrome- and peroxidase-coupled lectins. Effects of fixation methods on lectin-binding patterns were also compared. Un-induced mesenchymal cells and ureter bud of the early metanephros reacted with Concanavalin A, Lens culinaris, Ricinus communis I, and wheat germ agglutinins, whereas binding sites for both soybean and peanut (PNA) agglutinins were seen only in ureter bud tissue. On induction, PNA positivity rapidly appeared in the induced, condensed areas of the metanephrogenic mesenchyme. Early glomeruli expressed heterogeneously terminal galactosyl and N- acetylgalactosaminyl moieties in the podocytes. Later, these sites disappeared and were apparently covered by sialic acids. Endothelia also displayed a comparable sialylation of terminal saccharide moieties during maturation. Binding sites for many of the above lectins were also found in the developing proximal and distal tubules. Terminal fucosyl residues, characteristic of mature proximal tubules, appeared during day 13 of development. Dolichos biflorus agglutinin reactivity, typically seen in the collecting ducts, appeared by day 13. Griffonia simplicifolia-I-B4 isolectin reactivity was exclusively localized to endothelial in adult kidney cortex, but in embryonic kidneys reactivity with collecting duct and podocytes was also seen. These results suggest that the compartmentalized expression of cell glycoconjugates in adult mouse kidney is acquired in a sequential manner during development. Such sequential appearance of the mature glycosylation pattern probably reflects functional maturation of the nephron.
Volume 35,
Issue 1,
pp. 55-65,
01/01/1987
Copyright © 1987 by The Histochemical Society
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Wang, R. John, J. Chen, J. A. Richardson, J. M. Shelton, M. Bennett, X. J. Zhou, G. T. Nagami, Y. Zhang, Q. Q. Wu, et al. IRF-1 Promotes Inflammation Early after Ischemic Acute Kidney Injury J. Am. Soc. Nephrol., July 1, 2009; 20(7): 1544 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Shiba, Y. Yamaoka, H. Hagiwara, T. Takamatsu, H. Hamada, and T. Yokoyama Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region J. Cell Sci., January 1, 2009; 122(1): 44 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Truong, G. Kaler, A. Khandelwal, P. W. Swaan, and S. K. Nigam Multi-level Analysis of Organic Anion Transporters 1, 3, and 6 Reveals Major Differences in Structural Determinants of Antiviral Discrimination J. Biol. Chem., March 28, 2008; 283(13): 8654 - 8663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gao, D. J. Nolan, A. S. Mellick, K. Bambino, K. McDonnell, and V. Mittal Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis Science, January 11, 2008; 319(5860): 195 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yu, K. Hackmann, J. Gao, X. He, K. Piontek, M. A. Garcia-Gonzalez, L. F. Menezes, H. Xu, G. G. Germino, J. Zuo, et al. Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure PNAS, November 20, 2007; 104(47): 18688 - 18693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Nolan, A. Ciarrocchi, A. S. Mellick, J. S. Jaggi, K. Bambino, S. Gupta, E. Heikamp, M. R. McDevitt, D. A. Scheinberg, R. Benezra, et al. Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization Genes & Dev., June 15, 2007; 21(12): 1546 - 1558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-T. Cheng, M. Kim, M. T. Valerius, K. Surendran, K. Schuster-Gossler, A. Gossler, A. P. McMahon, and R. Kopan Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron Development, February 15, 2007; 134(4): 801 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Abuazza, A. Becker, S. S. Williams, S. Chakravarty, H.-T. Truong, F. Lin, and M. Baum Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1132 - F1141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sugiyama and T. Yokoyama Sustained cell proliferation of renal epithelial cells in mice with inv mutation. Genes Cells, October 1, 2006; 11(10): 1213 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamamoto, L. Cui, K. Johkura, K. Asanuma, Y. Okouchi, N. Ogiwara, and K. Sasaki Branching ducts similar to mesonephric ducts or ureteric buds in teratomas originating from mouse embryonic stem cells Am J Physiol Renal Physiol, January 1, 2006; 290(1): F52 - F60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen and Q. Al-Awqati Segmental expression of Notch and Hairy genes in nephrogenesis Am J Physiol Renal Physiol, May 1, 2005; 288(5): F939 - F952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Kanwar, J. Wada, S. Lin, F. R. Danesh, S. S. Chugh, Q. Yang, T. Banerjee, and J. W. Lomasney Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis Am J Physiol Renal Physiol, February 1, 2004; 286(2): F202 - F215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Thomson, S. Mentone, R. Kim, K. Earle, E. Delpire, S. Somlo, and P. S. Aronson Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD Am J Physiol Renal Physiol, November 1, 2003; 285(5): F870 - F880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gross, D. J. Morrison, D. P. Hyink, K. Georgas, M. A. English, M. Mericskay, S. Hosono, D. Sassoon, P. D. Wilson, M. Little, et al. The Receptor Tyrosine Kinase Regulator Sprouty1 Is a Target of the Tumor Suppressor WT1 and Important for Kidney Development J. Biol. Chem., October 17, 2003; 278(42): 41420 - 41430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-T. Cheng, J. H. Miner, M. Lin, M. G. Tansey, K. Roth, and R. Kopan {gamma}-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney Development, October 15, 2003; 130(20): 5031 - 5042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maeshima, S. Yamashita, K. Maeshima, I. Kojima, and Y. Nojima Activin A Produced by Ureteric Bud Is a Differentiation Factor For Metanephric Mesenchyme J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1523 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schneider, Y. Zhang, Y. Guan, L. S. Davis, and M. D. Breyer Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice Am J Physiol Renal Physiol, February 1, 2003; 284(2): F411 - F417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Shao, J. E. Johnson, J. A. Richardson, T. Hiesberger, and P. Igarashi A Minimal Ksp-Cadherin Promoter Linked to a Green Fluorescent Protein Reporter Gene Exhibits Tissue-Specific Expression in the Developing Kidney and Genitourinary Tract J. Am. Soc. Nephrol., July 1, 2002; 13(7): 1824 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. LEGALLICIER, G. TRUGNAN, G. MURPHY, B. LELONGT, P. RONCO, and P. FONTANGES Expression of the Type IV Collagenase System during Mouse Kidney Development and Tubule Segmentation J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2358 - 2369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sakurai, K. T. Bush, and S. K. Nigam Identification of pleiotrophin as a mesenchymal factor involved in ureteric bud branching morphogenesis Development, September 1, 2001; 128(17): 3283 - 3293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takacs-Jarrett, W. E. Sweeney, E. D. Avner, and C. U. Cotton Generation and phenotype of cell lines derived from CF and non-CF mice that carry the H-2Kb-tsA58 transgene Am J Physiol Cell Physiol, January 1, 2001; 280(1): C228 - C236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Phillips, L. J. Arend, A. J. Filson, D. J. Kojetin, J. L. Clendenon, S. Fang, and K. W. Dunn Three-Dimensional Imaging of Embryonic Mouse Kidney by Two-Photon Microscopy Am. J. Pathol., January 1, 2001; 158(1): 49 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. AREND, A. M. SMART, and J. P. BRIGGS Mouse {beta}6 Integrin Sequence, Pattern of Expression, and Role in Kidney Development J. Am. Soc. Nephrol., December 1, 2000; 11(12): 2297 - 2305. [Abstract] [Full Text]
|
|
|
|
|
|
J. Qiao, H. Sakurai, and S. K. Nigam Branching morphogenesis independent of mesenchymal-epithelial contact in the developing kidney PNAS, June 22, 1999; 96(13): 7330 - 7335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kraemer, R. Tournaire, V. Dejong, N. Montreau, D. Briane, C. Derbin, and B. Binétruy Rat Embryo Fibroblasts Transformed by c-Jun Display Highly Metastatic and Angiogenic Activities in Vivo and Deregulate Gene Expression of Both Angiogenic and Antiangiogenic Factors Cell Growth Differ., March 1, 1999; 10(3): 193 - 200. [Abstract] [Full Text]
|
|
|
|
|
|
S. Quaggin, L Schwartz, S Cui, P Igarashi, J Deimling, M Post, and J Rossant The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis Development, January 12, 1999; 126(24): 5771 - 5783. [Abstract] [PDF]
|
|
|
|
|
|
M. Takacs-Jarrett, W. E. Sweeney, E. D. Avner, and C. U. Cotton Morphological and functional characterization of a conditionally immortalized collecting tubule cell line Am J Physiol Renal Physiol, November 1, 1998; 275(5): F802 - F811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Wallner, Q. Yang, D. R. Peterson, J. Wada, and Y. S. Kanwar Relevance of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis Am J Physiol Renal Physiol, October 1, 1998; 275(4): F467 - F477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cho, L. Patterson, W. Brookhiser, S Mah, C Kintner, and G. Dressler Differential expression and function of cadherin-6 during renal epithelium development Development, January 3, 1998; 125(5): 803 - 812. [Abstract] [PDF]
|
|
|
|
|
|
I. Karavanova, L. Dove, J. Resau, and A. Perantoni Conditioned medium from a rat ureteric bud cell line in combination with bFGF induces complete differentiation of isolated metanephric mesenchyme Development, January 12, 1996; 122(12): 4159 - 4167. [Abstract] [PDF]
|
|
|
|
|
|
A Schuchardt, V D'Agati, V Pachnis, and F Costantini Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development Development, January 6, 1996; 122(6): 1919 - 1929. [Abstract] [PDF]
|
|
|
|
|
|
J Qiao, D Cohen, and D Herzlinger The metanephric blastema differentiates into collecting system and nephron epithelia in vitro Development, January 10, 1995; 121(10): 3207 - 3214. [Abstract] [PDF]
|
|
|
|
|
|
Q Bao and R. Hughes Galectin-3 expression and effects on cyst enlargement and tubulogenesis in kidney epithelial MDCK cells cultured in three-dimensional matrices in vitro J. Cell Sci., January 8, 1995; 108(8): 2791 - 2800. [Abstract] [PDF]
|
|
| Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact |
