Immunohistochemical localization of a low molecular weight surfactant- associated protein in human lungDS Phelps and HP Harding Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115. We used an antiserum to a hydrophobic 6 KD surfactant-associated protein to localize this protein in human lung tissue. This antiserum does not crossreact with the 35 KD surfactant-associated protein. By light microscopy using the indirect immunoperoxidase technique, the protein appears to be localized within Type II alveolar epithelial cells. Staining is also detectable in alveolar macrophages and occasionally within the lumina of alveoli and bronchioles. No staining was detected within the alveolar septa or in association with blood vessels. An identical distribution is seen for the 35 KD surfactant- associated protein using an antiserum specific for that protein.
Volume 35,
Issue 11,
pp. 1339-1342,
11/01/1987
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S. Lin, C.-L. Na, H. T. Akinbi, K. S. Apsley, J. A. Whitsett, and T. E. Weaver Surfactant Protein B (SP-B) -/- Mice Are Rescued by Restoration of SP-B Expression in Alveolar Type II Cells but Not Clara Cells J. Biol. Chem., July 2, 1999; 274(27): 19168 - 19174. [Abstract] [Full Text] [PDF] |
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D. Wang, M. Post, and E. Cutz Expression of Serotonin Receptor 2c in Rat Type II Pneumocytes Am. J. Respir. Cell Mol. Biol., June 1, 1999; 20(6): 1175 - 1180. [Abstract] [Full Text] |
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