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Distribution of vitamin B12 R binder in normal human tissues: an immunohistochemical study

H Kudo, G Ohshio, K Ogawa, Y Wakatsuki, M Inada, Y Hamashima and T Miyake

We studied the distribution of vitamin B12 R binder in various normal human tissues by use of an immunoperoxidase technique. Positive staining for R binder was observed in almost all glandular epithelia of digestive system, bronchial glands, renal proximal tubules, prostate, uterus, Fallopian tube, mammary gland, and sweat glands. The distribution of R binder was similar to that of lactoferrin and secretory component. These findings support the hypothesis that R binder plays a role in the local defense mechanism.

Volume 35, Issue 8, pp. 855-859, 08/01/1987
Copyright © 1987 by The Histochemical Society


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The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 1987