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Calcitonin gene-related peptide in human fetal lung and in neonatal lung disease

MD Johnson, ME Gray and MT Stahlman

Department of Pathology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232.

The ontogeny of calcitonin gene-related peptide immunoreactivity (CGRP- IR) was evaluated immunohistochemically in 67 human fetal or newborn lungs previously analyzed for calcitonin immunoreactivity (CT-IR). CGRP- IR was present by 10 weeks of gestation in rare, solitary neuroendocrine (NE) cells of developing conducting airways in two of eight first-trimester lungs. During the second trimester, cells with CGRP-IR were found consistently (21/23 fetuses). However, the numbers of positively staining cells did not appear to increase in these fetuses or in third-trimester infants dying of non-pulmonary causes. The highest concentrations of CGRP-IR cells were seen in lungs of premature infants with advancing chronic lung disease associated with bronchopulmonary dysplasia (BPD). CGRP-IR was seen earlier in gestation and in greater numbers of NE cells than was calcitonin immunoreactivity (CT-IR) reported previously in these same fetal lungs (Lab Invest 52:52, 1985). Its presence paralleled that of CT-IR in postnatal chronic lung disease.

Volume 36, Issue 2, pp. 199-204, 02/01/1988
Copyright © 1988 by The Histochemical Society


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