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Subcellular localization of blood group substances ABH in human salivary glands

M Cossu, A Riva and MS Lantini

Dipartimento di Citomorfologia, Universita' di Cagliari, Italia.

We investigated the subcellular localization of ABH antigens in human submandibular, sublingual, and buccal glands by applying a post- embedding immunogold method using monoclonal antibodies specific for A, B, and H antigens. In most glands the immunoreactivity was usually restricted to mucous cells, in which only secretory granules and sometimes Golgi cisternae were specifically labeled. A and B antigens were demonstrated only in the glands of type A, B, and AB subjects, while H antigen was visualized in glands from individuals of all blood types. Moreover, differences were observed in the relative distribution of ABH antigens, depending on the type of gland.

Volume 38, Issue 8, pp. 1165-1172, 08/01/1990
Copyright © 1990 by The Histochemical Society


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