|
|
|
|
 |
|||
|
|||
Surfactant protein A is localized at the corners of the pulmonary tubular myelin lattice
WF Voorhout, T Veenendaal, HP Haagsman, AJ Verkleij, LM van Golde and HJ Geuze
Department of Cell Biology, Medical School, University of Utrecht, The Netherlands.
Immunogold labeling on sections of a freeze-substituted tubular myelin- enriched fraction isolated from a bronchoalveolar lavage of rat lung showed that surfactant protein A (SP-A) occurs predominantly at the corners of the tubular myelin lattice. Seventy-nine percent of the gold particles were located within 20 nm from a corner. Extracellular SP-A was detected only in the tubular myelin lattice and not in vesicles or secreted lamellar bodies. Ultra-thin cryosections of rat lung fixed in vivo showed that intracellular SP-A was distributed homogeneously over the stacked membranes of lamellar bodies in alveolar Type II cells. The presence of SP-A at the corners of the tubular myelin lattice suggests an important role of this protein in the formation and/or maintenance of this highly ordered lattice.
Volume 39,
Issue 10,
pp. 1331-1336,
10/01/1991
Copyright © 1991 by The Histochemical Society
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. M. Hickman-Davis, Z. Wang, G. A. Fierro-Perez, P. R. Chess, G. P. Page, S. Matalon, and R. H. Notter Surfactant Dysfunction in SP-A-/- and iNOS-/- Mice with Mycoplasma Infection Am. J. Respir. Cell Mol. Biol., January 1, 2007; 36(1): 103 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nag, K. Rodriguez-Capote, A. K. Panda, L. Frederick, S. A. Hearn, N. O. Petersen, S. Schurch, and F. Possmayer Disparate effects of two phosphatidylcholine binding proteins, C-reactive protein and surfactant protein A, on pulmonary surfactant structure and function Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1145 - L1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ochs, G. Johnen, K.-M. Muller, T. Wahlers, S. Hawgood, J. Richter, and F. Brasch Intracellular and Intraalveolar Localization of Surfactant Protein A (SP-A) in the Parenchymal Region of the Human Lung Am. J. Respir. Cell Mol. Biol., January 1, 2002; 26(1): 91 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ikegami, B. M. Elhalwagi, N. Palaniyar, K. Dienger, T. Korfhagen, J. A. Whitsett, and F. X. McCormack The Collagen-like Region of Surfactant Protein A (SP-A) Is Required for Correction of Surfactant Structural and Functional Defects in the SP-A Null Mouse J. Biol. Chem., October 12, 2001; 276(42): 38542 - 38548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pol, R. Luetterforst, M. Lindsay, S. Heino, E. Ikonen, and R. G. Parton A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance J. Cell Biol., March 5, 2001; 152(5): 1057 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Miller, S. Orgeig, C. B. Daniels, and R. V. Baudinette Postnatal development and control of the pulmonary surfactant system in the tammar wallaby Macropus eugenii J. Exp. Biol., January 12, 2001; 204(23): 4031 - 4042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. Akinbi, R. Epaud, H. Bhatt, and T. E. Weaver Bacterial Killing Is Enhanced by Expression of Lysozyme in the Lungs of Transgenic Mice J. Immunol., November 15, 2000; 165(10): 5760 - 5766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. AWASTHI, J. J. COALSON, E. CROUCH, F. YANG, and R. J. KING Surfactant Proteins A and D in Premature Baboons with Chronic Lung Injury (Bronchopulmonary Dysplasia) . Evidence for an Inhibition of Secretion Am. J. Respir. Crit. Care Med., September 1, 1999; 160(3): 942 - 949. [Abstract] [Full Text]
|
|
|
|
|
|
J. Savov, R. Silbajoris, and S. L. Young Mechanical ventilation of rat lung: effect on surfactant forms Am J Physiol Lung Cell Mol Physiol, August 1, 1999; 277(2): L320 - L326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Rosenberg, F. Li, C. I. Smith, S. R. Reisher, and S. I. Feinstein Transcriptional activation and protein binding by two regions of the rat surfactant protein A promoter Am J Physiol Lung Cell Mol Physiol, July 1, 1999; 277(1): L134 - L141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Poulain, J. Akiyama, L. Allen, C. Brown, R. Chang, J. Goerke, L. Dobbs, and S. Hawgood Ultrastructure of Phospholipid Mixtures Reconstituted with Surfactant Proteins B and D Am. J. Respir. Cell Mol. Biol., May 1, 1999; 20(5): 1049 - 1058. [Abstract] [Full Text]
|
|
|
|
|
|
N. Palaniyar, R. A. Ridsdale, S. A. Hearn, F. Possmayer, and G. Harauz Formation of membrane lattice structures and their specific interactions with surfactant protein A Am J Physiol Lung Cell Mol Physiol, April 1, 1999; 276(4): L642 - L649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Osanai, R. J. Mason, and D. R. Voelker Trafficking of Newly Synthesized Surfactant Protein A in Isolated Rat Alveolar Type II Cells Am. J. Respir. Cell Mol. Biol., December 1, 1998; 19(6): 929 - 935. [Abstract] [Full Text]
|
|
|
|
|
|
E. C. Crouch Collectins and Pulmonary Host Defense Am. J. Respir. Cell Mol. Biol., August 1, 1998; 19(2): 177 - 201. [Abstract] [Full Text]
|
|
| Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact |