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CARBOHYDRATE AND CARBOHYDRATE METABOLITE UTILIZATION BY ENZYME SYSTEMS OF MOUSE BRAIN AND LIVER MITOCHONDRIA

H. G. DU BUY 1 and M. L. HESSELBACH 1

1 From the U. S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Microbiological Institute, Bethesda 14, Maryland

1. Both mouse brain and mouse liver preparations were found to utilize substrates characteristic of the following carbohydrate enzyme systems : the glycogen, glucose, fructose, mannose, fructose-1-phosphate (5), oxidative pentose phosphate (4), and tricarboxylic acid system.

2. Each of these enzyme systems was found on isolated brain mitochondria and a number on isolated liver mitochondria.

3. The implications of these findings in regard to the lability, normal enzyme system complement and functions of mitochondria are discussed.

Submitted on December 23, 1955


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