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A HISTOCHEMICAL INVESTIGATION OF NEUROSECRETORY SUBSTANCE IN THE RAT

A. HOWE 1 and A. G. E. PEARSE 1

1 Department of Pathology, Postgraduate Medical School of London

(1) The chemical nature of `neurosecretory substance' has been examined by a variety of histochemical methods in the rat.

(2) With the methods used it appears that this material is protein or polypeptide in character; the presence of lipid or carbohydrate is excluded, and it does not contain ribose nucleic acid.

(3) These findings are discussed in relation to the theory of neurosecretion and the source of posterior lobe hormones.

Submitted on May 14, 1956


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