Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae

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Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae

RG Parton

European Molecular Biology Laboratory, Heidelberg, Germany.

The ultrastructural distribution of the ganglioside GM1 was investigated in A431 cells. After fixation, the cells were frozen in liquid nitrogen, freeze-substituted, and then embedded in Lowicryl resin at -45 degrees C. By use of the cholera toxin-binding subunit adsorbed to gold as a specific probe to label on the sections, GM1 was shown to be present in endocytic organelles, in the trans-Golgi network, and on the plasma membrane, but was not detectable in the endoplasmic reticulum. GM1 was not distributed uniformly over the plasma membrane but was concentrated approximately four-fold in non- coated invaginations. These were identified as caveolae by labeling frozen sections of cholera toxin-gold surface-labeled cells with antibodies to VIP-21/caveolin. The results strengthen the functional analogy between caveolae and sorting domains of the TGN in polarized epithelial cells.

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A. A. Wolf, M. G. Jobling, S. Wimer-Mackin, M. Ferguson-Maltzman, J. L. Madara, R. K. Holmes, and W. I. Lencer
Ganglioside Structure Dictates Signal Transduction by Cholera Toxin and Association with Caveolae-like Membrane Domains in Polarized Epithelia
J. Cell Biol., May 18, 1998; 141(4): 917 - 927.
[Abstract] [Full Text] [PDF]

P. A. Orlandi and P. H. Fishman
Filipin-dependent Inhibition of Cholera Toxin: Evidence for Toxin Internalization and Activation through Caveolae-like Domains
J. Cell Biol., May 18, 1998; 141(4): 905 - 915.
[Abstract] [Full Text] [PDF]

M. Isshiki, J. Ando, R. Korenaga, H. Kogo, T. Fujimoto, T. Fujita, and A. Kamiya
Endothelial Ca2+ waves preferentially originate at specific loci in caveolin-rich cell edges
PNAS, April 28, 1998; 95(9): 5009 - 5014.
[Abstract] [Full Text] [PDF]

T. Ikezu, B. D. Trapp, K. S. Song, A. Schlegel, M. P. Lisanti, and T. Okamoto
Caveolae, Plasma Membrane Microdomains for alpha -Secretase-mediated Processing of the Amyloid Precursor Protein
J. Biol. Chem., April 24, 1998; 273(17): 10485 - 10495.
[Abstract] [Full Text] [PDF]

J. R. Henley, E. W.A. Krueger, B. J. Oswald, and M. A. McNiven
Dynamin-mediated Internalization of Caveolae
J. Cell Biol., April 6, 1998; 141(1): 85 - 99.
[Abstract] [Full Text] [PDF]

P. Oh, D. P. McIntosh, and J. E. Schnitzer
Dynamin at the Neck of Caveolae Mediates Their Budding to Form Transport Vesicles by GTP-driven Fission from the Plasma Membrane of Endothelium
J. Cell Biol., April 6, 1998; 141(1): 101 - 114.
[Abstract] [Full Text] [PDF]

A. Uittenbogaard, Y.-s. Ying, and E. J. Smart
Characterization of a Cytosolic Heat-shock Protein-Caveolin Chaperone Complex. INVOLVEMENT IN CHOLESTEROL TRAFFICKING
J. Biol. Chem., March 13, 1998; 273(11): 6525 - 6532.
[Abstract] [Full Text] [PDF]

D. Hailstones, L. S. Sleer, R. G. Parton, and K. K. Stanley
Regulation of caveolin and caveolae by cholesterol in MDCK cells
J. Lipid Res., February 1, 1998; 39(2): 369 - 379.
[Abstract] [Full Text]

F. B. Schapiro, C. Lingwood, W. Furuya, and S. Grinstein
pH-independent retrograde targeting of glycolipids to the Golgi complex
Am J Physiol Cell Physiol, February 1, 1998; 274(2): C319 - C332.
[Abstract] [Full Text] [PDF]

T. Ariga, W. D. Jarvis, and R. K. Yu
Role of sphingolipid-mediated cell death in neurodegenerative diseases
J. Lipid Res., January 1, 1998; 39(1): 1 - 16.
[Abstract] [Full Text]

R. Brown
Sphingolipid organization in biomembranes: what physical studies of model membranes reveal
J. Cell Sci., January 1, 1998; 111(1): 1 - 9.
[Abstract] [PDF]

P. L. Cameron, J. W. Ruffin, R. Bollag, H. Rasmussen, and R. S. Cameron
Identification of Caveolin and Caveolin-Related Proteins in the Brain
J. Neurosci., December 15, 1997; 17(24): 9520 - 9535.
[Abstract] [Full Text] [PDF]

T. P. Stauffer and T. Meyer
Compartmentalized IgE Receptor-mediated Signal Transduction in Living Cells
J. Cell Biol., December 15, 1997; 139(6): 1447 - 1454.
[Abstract] [Full Text] [PDF]

C. Lupu, C. A. Goodwin, A. D. Westmuckett, J. J. Emeis, M. F. Scully, V. V. Kakkar, and F. Lupu
Tissue Factor Pathway Inhibitor in Endothelial Cells Colocalizes With Glycolipid Microdomains/Caveolae : Regulatory Mechanism(s) of the Anticoagulant Properties of the Endothelium
Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2964 - 2974.
[Abstract] [Full Text]

J. Babitt, B. Trigatti, A. Rigotti, E. J. Smart, R. G.�W. Anderson, S. Xu, and M. Krieger
Murine SR-BI, a High Density Lipoprotein Receptor That Mediates Selective Lipid Uptake, Is N-Glycosylated and Fatty Acylated and Colocalizes with Plasma Membrane Caveolae
J. Biol. Chem., May 16, 1997; 272(20): 13242 - 13249.
[Abstract] [Full Text] [PDF]

N. Naslavsky, R. Stein, A. Yanai, G. Friedlander, and A. Taraboulos
Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform
J. Biol. Chem., March 7, 1997; 272(10): 6324 - 6331.
[Abstract] [Full Text] [PDF]

P. A. Orlandi and P. A. Orlandi
Protein-disulfide Isomerase-mediated Reduction of the A Subunit of Cholera Toxin in a Human Intestinal Cell Line
J. Biol. Chem., February 14, 1997; 272(7): 4591 - 4599.
[Abstract] [Full Text] [PDF]