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Developing human lung and kidney are major sites for synthesis of bone morphogenetic protein-3 (osteogenin)

S Vukicevic, MN Helder and FP Luyten

Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892.

Bone morphogenetic protein-3 (BMP-3; osteogenin) is a member of the transforming growth factor-beta superfamily. We used human BMP-3 cDNA probes and a specific BMP-3 polyclonal peptide antibody to analyze BMP- 3 expression and synthesis in human fetal and adult tissues. Northern blot hybridization revealed two mRNA species of 7 and 3 KB. High levels of BMP-3 mRNA were found in fetal lungs. By in situ hybridization, the BMP-3 transcripts were found in lung bronchial epithelium, straight collecting kidney tubules, intestinal mucosa, perichondrium, periosteum, and osteoblasts of human embryos of 6-14 weeks' gestation. Cellular BMP-3 immunostaining co-localized with the distribution of RNA. In addition, bone matrix showed intensive BMP-3 staining. These data suggest that although BMP-3 has been isolated from bone matrix, it may have additional regulatory roles in the morphogenesis and/or function of human lung, kidney, and intestine.

Volume 42, Issue 7, pp. 869-875, 07/01/1994
Copyright © 1994 by The Histochemical Society


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