|
|
|
|
 |
|||
|
|||
72 KD and 92 KD type IV collagenase, type IV collagen, and laminin mRNAs in breast cancer: a study by in situ hybridization
Y Soini, T Hurskainen, M Hoyhtya, A Oikarinen and H Autio-Harmainen
Department of Pathology, University of Oulu, Finland.
It is widely accepted that basement membrane (BM) components are synthesized by epithelial cells and that production of BM-degrading proteases by cancer cells is necessary for invasive growth. In this study we used nucleic acid in situ hybridization (ISH) to investigate the presence of mRNAs for 72 KD and 92 KD Type IV collagenase, alpha 1 (IV) chain of Type IV collagen, and laminin B1 chain in 20 breast carcinomas of various histological types. The mRNA signals for 72 KD Type IV collagenase, Type IV collagen, and laminin were much more abundant in stromal fibroblasts and endothelial cells than in carcinoma cells. The signal for 92 KD Type IV collagenase mRNA was strong in carcinoma cells and considerably weaker in stromal fibroblasts and endothelial cells. Labeling for 72 KD and 92 KD Type IV collagenase mRNA was also found in benign fibroadenomas and for 92 KD Type IV collagenase in non-neoplastic ducts and acini. The results indicate that stromal cells have a more important role in the synthesis and degradation of BMs in breast carcinomas than previously thought and that production of these enzymes is not restricted to malignancy.
Volume 42,
Issue 7,
pp. 945-951,
07/01/1994
Copyright © 1994 by The Histochemical Society
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. M. Barnett, G. W. McCollum, J. A. Fowler, J. J.-W. Duan, J. D. Kay, R.-Q. Liu, D. P. Bingaman, and J. S. Penn Pharmacologic and Genetic Manipulation of MMP-2 and -9 Affects Retinal Neovascularization in Rodent Models of OIR Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 907 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Nair, J. Solway, and D. D. Boyd Expression Cloning Identifies Transgelin (SM22) as a Novel Repressor of 92-kDa Type IV Collagenase (MMP-9) Expression J. Biol. Chem., September 8, 2006; 281(36): 26424 - 26436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Kamat, M. Fletcher, L. M. Gruman, P. Mueller, A. Lopez, C. N. Landen Jr., L. Han, D. M. Gershenson, and A. K. Sood The Clinical Relevance of Stromal Matrix Metalloproteinase Expression in Ovarian Cancer Clin. Cancer Res., March 15, 2006; 12(6): 1707 - 1714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Pellikainen, K. M. Ropponen, V. V. Kataja, J. K. Kellokoski, M. J. Eskelinen, and V.-M. Kosma Expression of Matrix Metalloproteinase (MMP)-2 and MMP-9 in Breast Cancer with a Special Reference to Activator Protein-2, HER2, and Prognosis Clin. Cancer Res., November 15, 2004; 10(22): 7621 - 7628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-G. Zhao, A.-Z. Xiao, H. I. Park, R. G. Newcomer, M. Yan, Y.-G. Man, S. C. Heffelfinger, and Q.-X. A. Sang Endometase/Matrilysin-2 in Human Breast Ductal Carcinoma in Situ and Its Inhibition by Tissue Inhibitors of Metalloproteinases-2 and -4: A Putative Role in the Initiation of Breast Cancer Invasion Cancer Res., January 15, 2004; 64(2): 590 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mannello and M. Sebastiani Zymographic Analyses and Measurement of Matrix Metalloproteinase-2 and -9 in Nipple Aspirate Fluids Clin. Chem., September 1, 2003; 49(9): 1546 - 1550. [Full Text] [PDF]
|
|
|
|
|
|
L. Berglin, S. Sarman, I. van der Ploeg, B. Steen, Y. Ming, S. Itohara, S. Seregard, and A. Kvanta Reduced Choroidal Neovascular Membrane Formation in Matrix Metalloproteinase-2-Deficient Mice Invest. Ophthalmol. Vis. Sci., January 1, 2003; 44(1): 403 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Pepper Role of the Matrix Metalloproteinase and Plasminogen Activator-Plasmin Systems in Angiogenesis Arterioscler. Thromb. Vasc. Biol., July 1, 2001; 21(7): 1104 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zucker, M. Hymowitz, E. E. Rollo, R. Mann, C. E. Conner, J. Cao, H. D. Foda, D. C. Tompkins, and B. P. Toole Tumorigenic Potential of Extracellular Matrix Metalloproteinase Inducer Am. J. Pathol., June 1, 2001; 158(6): 1921 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Davis, K. Pintar Allen, R Salazar, and S. Maxwell Matrix metalloproteinase-1 and -9 activation by plasmin regulates a novel endothelial cell-mediated mechanism of collagen gel contraction and capillary tube regression in three-dimensional collagen matrices J. Cell Sci., January 3, 2001; 114(5): 917 - 930. [Abstract] [PDF]
|
|
|
|
|
|
M. E. Kupferman, M. E. Fini, W. J. Muller, R. Weber, Y. Cheng, and R. J. Muschel Matrix Metalloproteinase 9 Promoter Activity Is Induced Coincident with Invasion during Tumor Progression Am. J. Pathol., December 1, 2000; 157(6): 1777 - 1783. [Abstract] [Full Text] [PDF]
|
|
| Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact |