|
|
|
|
 |
|||
|
|||
Elastic lamina growth in the developing mouse aorta
EC Davis
Department of Anatomy, McGill University, Montreal, Quebec, Canada.
The growth and development of elastic laminae in the mouse aortic media were investigated by light and electron microscopic autoradiography after a single SC injection of L-[3,4-3H]-valine. Because of the remarkable stability of elastin, radiolabel incorporated into the elastic laminae during early stages of aortic development can be identified in the mature vessel. Light microscopic autoradiographs of aortae from mice injected with radiolabeled valine at 3, 14, or 21 days of postnatal age and sacrificed at 4 months of age showed silver grains evenly distributed around the circumference of the vessel, suggesting uniform elastic lamina growth. Electron microscopic autoradiographs of aortae from mice injected at 3 and 14 days' postnatal age and killed at 4 months of age showed the elastin initially deposited at 3 days to be in the center of the lamina, whereas the elastin deposited at 14 days remained peripherally located. These observations suggest that elastin deposited early in development does not undergo any significant redistribution during growth of the vessel. Because the aorta continues to increase in diameter after the elastic laminae are essentially complete, the fenestrations in the laminae were investigated as possible sites of further expansion of the laminae. In aortae from mice injected at 3 days and sacrificed at 4 days of postnatal age, the edges of the elastic lamina that border on fenestrations showed a large number of silver grains. Regions of the elastic lamina at some distance from the fenestration, however, appeared to be associated with fewer grains. Results from this study not only present unique observations of elastin deposition in developing elastic laminae but also provide evidence that the fenestrations in the elastic laminae may play a role in their continued expansion during later stages of aortic development.
Volume 43,
Issue 11,
pp. 1115-1123,
11/01/1995
Copyright © 1995 by The Histochemical Society
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. M. Arribas, A. M. Briones, C. Bellingham, M. C. Gonzalez, M. Salaices, K. Liu, Y. Wang, and A. Hinek Heightened aberrant deposition of hard-wearing elastin in conduit arteries of prehypertensive SHR is associated with increased stiffness and inward remodeling Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2299 - H2307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Koudsi, J. Oldroyd, P. McElduff, M. Banerjee, A. Vyas, and J. K. Cruickshank Maternal and Neonatal Influences on, and Reproducibility of, Neonatal Aortic Pulse Wave Velocity Hypertension, January 1, 2007; 49(1): 225 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Gonzalez, A. M. Briones, B. Somoza, C. J. Daly, E. Vila, B. Starcher, J. C. McGrath, M. C. Gonzalez, and S. M. Arribas Postnatal alterations in elastic fiber organization precede resistance artery narrowing in SHR Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H804 - H812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Huang, X. Guo, and G. S. Kassab Axial nonuniformity of geometric and mechanical properties of mouse aorta is increased during postnatal growth Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H657 - H664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. S. Jackson, D. Dajnowiec, A. I. Gotlieb, and B. L. Langille Partial Off-Loading of Longitudinal Tension Induces Arterial Tortuosity Arterioscler. Thromb. Vasc. Biol., May 1, 2005; 25(5): 957 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. S. Jackson, A. I. Gotlieb, and B. L. Langille Wall Tissue Remodeling Regulates Longitudinal Tension in Arteries Circ. Res., May 3, 2002; 90(8): 918 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Boumaza, S. M. Arribas, M. Osborne-Pellegrin, J. C. McGrath, S. Laurent, P. Lacolley, and P. Challande Fenestrations of the Carotid Internal Elastic Lamina and Structural Adaptation in Stroke-Prone Spontaneously Hypertensive Rats Hypertension, April 1, 2001; 37(4): 1101 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Y. Wong and B. L. Langille Developmental Remodeling of the Internal Elastic Lamina of Rabbit Arteries : Effect of Blood Flow Circ. Res., May 1, 1996; 78(5): 799 - 805. [Abstract] [Full Text]
|
|
|
|
|
|
Z. S. Jackson, A. I. Gotlieb, and B. L. Langille Wall Tissue Remodeling Regulates Longitudinal Tension in Arteries Circ. Res., May 3, 2002; 90(8): 918 - 925. [Abstract] [Full Text] [PDF]
|
|
| Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact |