Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sincock, P. M.
Right arrow Articles by Ashman, L. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sincock, P. M.
Right arrow Articles by Ashman, L. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry, Vol. 45, 515-526, Copyright © 1997 by The Histochemical Society, Inc.

ARTICLE

Localization of the Transmembrane 4 Superfamily (TM4SF) Member PETA-3 (CD151) in Normal Human Tissues: Comparison with CD9, CD63, and {alpha}5ß1 Integrin

Paul M. Sincocka, Graham Mayrhoferb, and Leonie K. Ashmana
a Leukemia Research Unit, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, and Department of Medicine, The University of Adelaide, Adelaide, Australia
b Department of Microbiology and Immunology, The University of Adelaide, Adelaide, Australia

Correspondence to: Leonie K. Ashman, Leukemia Research Unit, Hanson Centre for Cancer Research, IMVS, PO Box 14, Rundle Mall, Adelaide 5000, Australia.

It has recently been shown that several members of the tetraspan superfamily, including CD9 and CD63, associate with each other and with ß1 integrins. In this study, we examined the distribution of a recently identified tetraspan, PETA-3 (CD151), and of CD9, CD63, {alpha}5ß1, and the integrin ß1 chain in normal human tissues by the indirect immunoperoxidase and alkaline phosphatase-anti-alkaline phosphatase techniques. PETA-3 showed a broad distribution and was expressed by endothelium, epithelium, Schwann cells, and dendritic cells and by skeletal, smooth, and cardiac muscle. Expression in skin was mostly restricted to the basal cells of the epidermis and was downregulated on differentiation. In the small intestine, PETA-3 was expressed by crypt and villous enterocytes with a mostly basolateral distribution, but was not detectable on the brush border. CD9 was expressed on the plasma membrane of enterocytes in crypts and at the bases of the villi whereas CD63 demonstrated a unique granular appearance concentrated in the apical cytoplasm below the brush border. The findings of this study show co-localization of PETA-3 with CD9, CD63, {alpha}5ß1, and ß1 in particular tissues, demonstrating that tetraspan/integrin complexes may occur. However, the lack of co-localization of these antigens in other tissues also implies distinct roles for these molecules. (J Histochem Cytochem 45:515-525, 1997)

Key Words: PETA-3, CD151, CD9, CD63, TM4SF, integrin


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
F. Zhang, J. Kotha, L. K. Jennings, and X. A. Zhang
Tetraspanins and vascular functions
Cardiovasc Res, July 1, 2009; 83(1): 7 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Schroder, R. Lullmann-Rauch, N. Himmerkus, I. Pleines, B. Nieswandt, Z. Orinska, F. Koch-Nolte, B. Schroder, M. Bleich, and P. Saftig
Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function
Mol. Cell. Biol., February 15, 2009; 29(4): 1083 - 1094.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C.-W. Chien, S.-C. Lin, Y.-Y. Lai, B.-W. Lin, S.-C. Lin, J.-C. Lee, and S.-J. Tsai
Regulation of CD151 by Hypoxia Controls Cell Adhesion and Metastasis in Colorectal Cancer
Clin. Cancer Res., December 15, 2008; 14(24): 8043 - 8051.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. G. Ng, I. Coppens, D. Govindarajan, J. Pisciotta, V. Shulaev, and D. E. Griffin
Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity
PNAS, October 21, 2008; 105(42): 16326 - 16331.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. M. Baleato, P. L. Guthrie, M.-C. Gubler, L. K. Ashman, and S. Roselli
Deletion of Cd151 Results in a Strain-Dependent Glomerular Disease Due to Severe Alterations of the Glomerular Basement Membrane
Am. J. Pathol., October 1, 2008; 173(4): 927 - 937.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Baba, M. Okamoto, T. Hamasaki, S. Horai, X. Wang, Y. Ito, Y. Suda, and N. Arima
Highly Enhanced Expression of CD70 on Human T-Lymphotropic Virus Type 1-Carrying T-Cell Lines and Adult T-Cell Leukemia Cells
J. Virol., April 15, 2008; 82(8): 3843 - 3852.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Liu, B. He, W. M. Liu, D. Zhou, J. V. Cox, and X. A. Zhang
Tetraspanin CD151 Promotes Cell Migration by Regulating Integrin Trafficking
J. Biol. Chem., October 26, 2007; 282(43): 31631 - 31642.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Takeda, A. R. Kazarov, C. E. Butterfield, B. D. Hopkins, L. E. Benjamin, A. Kaipainen, and M. E. Hemler
Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro
Blood, February 15, 2007; 109(4): 1524 - 1532.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
R. Hajj, T. Baranek, R. Le Naour, P. Lesimple, E. Puchelle, and C. Coraux
Basal Cells of the Human Adult Airway Surface Epithelium Retain Transit-Amplifying Cell Properties
Stem Cells, January 1, 2007; 25(1): 139 - 148.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. Gullberg, A. V. Keita, S. Y. Salim, M. Andersson, K. D. Caldwell, J. D. Soderholm, and P. Artursson
Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches
J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 632 - 639.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
N. Sachs, M. Kreft, M. A. van den Bergh Weerman, A. J. Beynon, T. A. Peters, J. J. Weening, and A. Sonnenberg
Kidney failure in mice lacking the tetraspanin CD151
J. Cell Biol., October 9, 2006; 175(1): 33 - 39.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I.-K. Hong, Y.-J. Jin, H.-J. Byun, D.-I. Jeoung, Y.-M. Kim, and H. Lee
Homophilic Interactions of Tetraspanin CD151 Up-regulate Motility and Matrix Metalloproteinase-9 Expression of Human Melanoma Cells through Adhesion-dependent c-Jun Activation Signaling Pathways
J. Biol. Chem., August 25, 2006; 281(34): 24279 - 24292.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. E. Winterwood, A. Varzavand, M. N. Meland, L. K. Ashman, and C. S. Stipp
A Critical Role for Tetraspanin CD151 in {alpha}3beta1 and {alpha}6beta4 Integrin-dependent Tumor Cell Functions on Laminin-5
Mol. Biol. Cell, June 1, 2006; 17(6): 2707 - 2721.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
F. Martin, D. M. Roth, D. A. Jans, C. W. Pouton, L. J. Partridge, P. N. Monk, and G. W. Moseley
Tetraspanins in Viral Infections: a Fundamental Role in Viral Biology?
J. Virol., September 1, 2005; 79(17): 10839 - 10851.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. Parsons-Wingerter, I. M. Kasman, S. Norberg, A. Magnussen, S. Zanivan, A. Rissone, P. Baluk, C. J. Favre, U. Jeffry, R. Murray, et al.
Uniform Overexpression and Rapid Accessibility of {alpha}5{beta}1 Integrin on Blood Vessels in Tumors
Am. J. Pathol., July 1, 2005; 167(1): 193 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Masuda, K. Wada, A. Nakajima, M. Okura, C. Kudo, T. Kadowaki, M. Kogo, and Y. Kamisaki
Critical Role of Peroxisome Proliferator-Activated Receptor {gamma} on Anoikis and Invasion of Squamous Cell Carcinoma
Clin. Cancer Res., June 1, 2005; 11(11): 4012 - 4021.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Pfistershammer, O. Majdic, J. Stockl, G. Zlabinger, S. Kirchberger, P. Steinberger, and W. Knapp
CD63 as an Activation-Linked T Cell Costimulatory Element
J. Immunol., November 15, 2004; 173(10): 6000 - 6008.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
V. Karamatic Crew, N. Burton, A. Kagan, C. A. Green, C. Levene, F. Flinter, R. L. Brady, G. Daniels, and D. J. Anstee
CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin
Blood, October 15, 2004; 104(8): 2217 - 2223.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L.-M. Lau, J. L. Wee, M. D. Wright, G. W. Moseley, P. M. Hogarth, L. K. Ashman, and D. E. Jackson
The tetraspanin superfamily member CD151 regulates outside-in integrin {alpha}IIb{beta}3 signaling and platelet function
Blood, October 15, 2004; 104(8): 2368 - 2375.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. D. Wright, S. M. Geary, S. Fitter, G. W. Moseley, L.-M. Lau, K.-C. Sheng, V. Apostolopoulos, E. G. Stanley, D. E. Jackson, and L. K. Ashman
Characterization of Mice Lacking the Tetraspanin Superfamily Member CD151
Mol. Cell. Biol., July 1, 2004; 24(13): 5978 - 5988.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Duffield, E.-J. Kamsteeg, A. N. Brown, P. Pagel, and M. J. Caplan
The tetraspanin CD63 enhances the internalization of the H,K-ATPase {beta}-subunit
PNAS, December 23, 2003; 100(26): 15560 - 15565.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
N. Chattopadhyay, Z. Wang, L. K. Ashman, S. M. Brady-Kalnay, and J. A. Kreidberg
{alpha}3{beta}1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTP{micro} expression and cell-cell adhesion
J. Cell Biol., December 22, 2003; 163(6): 1351 - 1362.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. D. Gutierrez-Lopez, S. Ovalle, M. Yanez-Mo, N. Sanchez-Sanchez, E. Rubinstein, N. Olmo, M. A. Lizarbe, F. Sanchez-Madrid, and C. Cabanas
A Functionally Relevant Conformational Epitope on the CD9 Tetraspanin Depends on the Association with Activated beta 1 Integrin
J. Biol. Chem., January 3, 2003; 278(1): 208 - 218.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. A. Cook, C. M. Longhurst, S. Grgurevich, S. Cholera, J. T. Crossno Jr, and L. K. Jennings
Identification of CD9 extracellular domains important in regulation of CHO cell adhesion to fibronectin and fibronectin pericellular matrix assembly
Blood, December 15, 2002; 100(13): 4502 - 4511.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L. M. T. Sterk, C. A. W. Geuijen, J. G. van den Berg, N. Claessen, J. J. Weening, and A. Sonnenberg
Association of the tetraspanin CD151 with the laminin-binding integrins {alpha}3{beta}1, {alpha}6{beta}1, {alpha}6{beta}4 and {alpha}7{beta}1 in cells in culture and in vivo
J. Cell Sci., March 15, 2002; 115(6): 1161 - 1173.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Tokuhara, H. Hasegawa, N. Hattori, H. Ishida, T. Taki, S. Tachibana, S. Sasaki, and M. Miyake
Clinical Significance of CD151 Gene Expression in Non-Small Cell Lung Cancer
Clin. Cancer Res., December 1, 2001; 7(12): 4109 - 4114.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. K. Tiwari-Woodruff, A. G. Buznikov, T. Q. Vu, P. E. Micevych, K. Chen, H. I. Kornblum, and J. M. Bronstein
OSP/Claudin-11 Forms a Complex with a Novel Member of the Tetraspanin Super Family and {beta}1 Integrin and Regulates Proliferation and Migration of Oligodendrocytes
J. Cell Biol., April 16, 2001; 153(2): 295 - 306.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y. Nakamura, K. Handa, R. Iwamoto, T. Tsukamoto, M. Takahasi, and E. Mekada
Immunohistochemical Distribution of CD9, Heparin Binding Epidermal Growth Factor-like Growth Factor, and Integrin {{alpha}}3{beta}1 in Normal Human Tissues
J. Histochem. Cytochem., April 1, 2001; 49(4): 439 - 444.
[Abstract] [Full Text]

Home page
 JCBHome page
L. M.Th. Sterk, C. A.W. Geuijen, L. C.J.M. Oomen, J. Calafat, H. Janssen, and A. Sonnenberg
The Tetraspan Molecule CD151, a Novel Constituent of Hemidesmosomes, Associates with the Integrin {alpha}6{beta}4 and May Regulate the Spatial Organization of Hemidesmosomes
J. Cell Biol., May 15, 2000; 149(4): 969 - 982.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. L. Yauch, A. R. Kazarov, B. Desai, R. T. Lee, and M. E. Hemler
Direct Extracellular Contact between Integrin alpha 3beta 1 and TM4SF Protein CD151
J. Biol. Chem., March 24, 2000; 275(13): 9230 - 9238.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
F. Le Naour, E. Rubinstein, C. Jasmin, M. Prenant, and C. Boucheix
Severely Reduced Female Fertility in CD9-Deficient Mice
Science, January 14, 2000; 287(5451): 319 - 321.
[Abstract] [Full Text]

Home page
 J. Cell Sci.Home page
C. Stipp and M. Hemler
Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth
J. Cell Sci., January 6, 2000; 113(11): 1871 - 1882.
[Abstract] [PDF]

Home page
 JCBHome page
I. Tachibana and M. E. Hemler
Role of Transmembrane 4 Superfamily (TM4SF) Proteins CD9 and CD81 in Muscle Cell Fusion and Myotube Maintenance
J. Cell Biol., August 23, 1999; 146(4): 893 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. E. Testa, P. C. Brooks, J.-M. Lin, and J. P. Quigley
Eukaryotic Expression Cloning with an Antimetastatic Monoclonal Antibody Identifies a Tetraspanin (PETA-3/CD151) as an Effector of Human TumorCell Migration and Metastasis
Cancer Res., August 1, 1999; 59(15): 3812 - 3820.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
P. Sincock, S Fitter, R. Parton, M. Berndt, J. Gamble, and L. Ashman
PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function
J. Cell Sci., January 3, 1999; 112(6): 833 - 844.
[Abstract] [PDF]

Home page
 Mol. Biol. CellHome page
R. L. Yauch, F. Berditchevski, M. B. Harler, J. Reichner, and M. E. Hemler
Highly Stoichiometric, Stable, and Specific Association of Integrin alpha 3beta 1 with CD151 Provides a Major Link to Phosphatidylinositol 4-Kinase, and May Regulate Cell Migration
Mol. Biol. Cell, October 1, 1998; 9(10): 2751 - 2765.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
H. Hasegawa, T. Nomura, K. Kishimoto, K. Yanagisawa, and S. Fujita
SFA-1/PETA-3 (CD151), a Member of the Transmembrane 4 Superfamily, Associates Preferentially with {alpha}5{beta}1 Integrin and Regulates Adhesion of Human T Cell Leukemia Virus Type 1-Infected T Cells to Fibronectin
J. Immunol., September 15, 1998; 161(6): 3087 - 3095.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Yanez-Mo, A. Alfranca, C. Cabanas, M. Marazuela, R. Tejedor, M. Angeles Ursa, L. K. Ashman, M. O. de Landazuri, and F. Sanchez-Madrid
Regulation of Endothelial Cell Motility by Complexes of Tetraspan Molecules CD81/TAPA-1 and CD151/PETA-3 with alpha 3beta 1 Integrin Localized at Endothelial Lateral Junctions
J. Cell Biol., May 4, 1998; 141(3): 791 - 804.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. J. Shattil, H. Kashiwagi, and N. Pampori
Integrin Signaling: The Platelet Paradigm
Blood, April 15, 1998; 91(8): 2645 - 2657.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Charrin, F. Le Naour, M. Oualid, M. Billard, G. Faure, S. M. Hanash, C. Boucheix, and E. Rubinstein
The Major CD9 and CD81 Molecular Partner. IDENTIFICATION AND CHARACTERIZATION OF THE COMPLEXES
J. Biol. Chem., April 20, 2001; 276(17): 14329 - 14337.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 1997

 
Purchase HCS Short Course Manual on HCS site