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ARTICLE |
Rat Endocrine Pancreatic Development in Relation to Two Homeobox Gene Products (Pdx-1 and Nkx 6.1)
Anne Østera, Jan Jensenb, Palle Serupb, Philip Galanteb, Ole D. Madsenb, and Lars-Inge Larssonaa Department of Molecular Cell Biology, Statens Seruminstitut, Copenhagen
b Hagedorn Research Institute, Gentofte, Denmark
Correspondence to: Lars-Inge Larsson, Dept. of Molecular Cell Biology, Statens Seruminstitut, Artillerivej 5, Bldg. 81, DK-2300 Copenhagen S, Denmark.
We studied the distribution of the homeodomain proteins Pdx-1 and Nkx 6.1 in the developing rat pancreas. During early development, nuclear staining for both Pdx-1 and Nkx 6.1 occurred in most epithelial cells of the pancreatic anlage. Subsequently, Nkx 6.1 became more ß-cell-restricted, and Pdx-1 also occurred in other islet cell types and in the duodenal epithelium. During early pancreatic development, cells co-storing insulin and glucagon were regularly detected. The vast majority of these did not possess nuclear staining for either Pdx-1 or Nkx 6.1. Subsequently, cells storing insulin only appeared. Such cells displayed strongly Pdx-1- and Nkx 6.1-positive nuclei. Therefore, Nkx 6.1, like Pdx-1, may be an important factor in pancreatic development and in mature insulin cell function.
(J Histochem Cytochem 46:707–715, 1998)
Key Words: homeodomain proteins, Nkx 6.1, Pdx-1, insulin, pancreatic polypeptide, glucagon
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