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Journal of Histochemistry and Cytochemistry, Vol. 46, 863-864, July 1998, Copyright © 1998, The Histochemical Society, Inc.

BRIEF REPORT

Intranuclear Distribution of HMGI/Y Proteins: An Immunocytochemical Study

Alberto M. Martellia, Massimo Ricciob, Renato Bareggia, Guidalberto Manfiolettic, Giovanna Tabellinia, Giovanna Baldinia, Paola Narduccia, and Vincenzo Giancottic
a Dipartimento di Morfologia Umana, Università di Trieste, Trieste, Italy
b Istituto di Citomorfologia Normale e Patologica del CNR, Bologna, Italy
c Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università di Trieste, Trieste, Italy

Correspondence to: Alberto M. Martelli, Dipartimento di Morfologia Umana, Università di Trieste, via Manzoni 16, I-34138 Trieste, Italy.

The intranuclear distribution of HMGI/Y proteins was analyzed by immunofluorescent staining in several cell lines using a polyclonal antibody that stained a fibrogranular network. In actively growing 3T3 fibroblasts, HMGI/Y proteins were mainly localized to heterochromatin masses, whereas in quiescent cells they were more diffusely distributed. Double labeling experiments showed a co-localization of HMGI/Y with DNA topoisomerase II{alpha}. These results are in agreement with previously published biochemical data and indicate a possible involvement of HMGI/Y proteins in several nuclear functions, including chromatin organization and gene expression. (J Histochem Cytochem 46: 863–864, 1998)

Key Words: HMGI/Y proteins, 3T3 fibroblasts, immunofluorescent staining, heterochromatin


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