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Journal of Histochemistry and Cytochemistry, Vol. 47, 1481-1486, November 1999, Copyright © 1999, The Histochemical Society, Inc.

BRIEF REPORT

55-kD Actin-bundling Protein (p55) Is a Specific Marker for Identifying Vascular Dendritic Cells

Yuri V. Bobrysheva and Reginald S.A. Lorda
a Surgical Professorial Unit, St. Vincent's Hospital, Darlinghurst, Sydney, NSW, Australia

Correspondence to: Yuri V. Bobryshev, Surgical Professorial Unit, Level 17 O'Brien Building, St. Vincent's Hospital, Darlinghurst NSW 2010, Australia.

Compared with other members of the dendritic cell family, the antigen profile of the recently recognized vascular dendritic cells has received limited attention. This study demonstrates that vascular dendritic cells in the human aorta and carotid arteries express 55-kD actin-bundling protein (p55), a specific marker for blood dendritic cells and Langerhans cells. This finding will facilitate screening of dendritic cells during their isolation from the arterial wall, as well as other investigations. (J Histochem Cytochem 47:1481–1486, 1999)

Key Words: arteries, intima, atherosclerosis, dendritic cells, 55-kD actin-bundling protein, (p55), CD1a, E-cadherin, S-100


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