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Journal of Histochemistry and Cytochemistry, Vol. 47, 817-822, June 1999, Copyright © 1999, The Histochemical Society, Inc.

ARTICLE

Expression of the MUC 6 Mucin Gene in Development of the Human Kidney and Male Genital Ducts

Colm J. Reida and Ann Harrisa
a Paediatric Molecular Genetics, Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

Correspondence to: Ann Harris, Paediatric Molecular Genetics, Inst. of Molecular Medicine, Oxford Univ., John Radcliffe Hospital, Oxford, OX3 9DU, UK.

The MUC 6 mucin cDNA was isolated from a human stomach cDNA library and has been shown to be expressed in a number of other tissues in the gastrointestinal tract, including the gallbladder, pancreas, and parts of the ileum and colon. Here we establish that MUC 6 is expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. MUC 6 transcripts were detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation. Traces of MUC 6 mRNA were seen in the collecting ducts but not elsewhere in the developing kidney, and MUC 6 glycoprotein was detected in the epithelium of ureteric buds and collecting ducts. MUC 6 transcripts were absent from adult kidney. This pattern of expression of MUC 6 in the developing kidney suggests a role in epithelial organogenesis. MUC 6 transcripts were also present at low levels in mid-trimester epididymal epithelium. (J Histochem Cytochem 47:817–821, 1999)

Key Words: MUC 6, mucin, kidney development


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