Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Olivieri, G.
Right arrow Articles by Miescher, G. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Olivieri, G.
Right arrow Articles by Miescher, G. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry, Vol. 47, 855-862, July 1999, Copyright © 1999, The Histochemical Society, Inc.

ARTICLE

Immunohistochemical Localization of EphA5 in the Adult Human Central Nervous System

Gianfranco Olivieria and Guido C. Miescherb
a Laboratory for Molecular Gerontology, Psychiatric University Hospital, Basel, Switzerland
b Departments of Clinical Neurology and Research, University Hospitals, Basel, Switzerland

Correspondence to: Gianfranco Olivieri, Lab. for Medical Gerontology, Psychiatric University Hospital, CH-4025 Basel, Switzerland.

To better understand the functional role of EphA5 in the adult human central nervous system (CNS), we performed an immunohistochemical mapping study. EphA5, like other members of the Elk/Eph family of receptor tyrosine kinases, was widely distributed in CNS neurons. However, the distribution of the neuronal staining was not uniform. The abundance of stained neurons appeared to increase from the forebrain to the hindbrain and spinal cord. Glial and endothelial tissue was unstained. These findings are consistent with the existence of receptor and ligand gradients in different brain regions. The localization of EphA5 to motor and sensory neurons is consistent with a role of EphA5 in neural plasticity, cell–cell recognition, and topographical orientation of neuronal systems. (J Histochem Cytochem 47:855–861, 1999)

Key Words: EphA5, receptor tyrosine kinase, immunocytochemistry, distribution, human CNS, neuron


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Br. J. Ophthalmol.Home page
P Meyer, M Pache, K U Loeffler, L Brydon, R Jockers, J Flammer, A Wirz-Justice, and E Savaskan
Melatonin MT-1-receptor immunoreactivity in the human eye
Br. J. Ophthalmol., September 1, 2002; 86(9): 1053 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Lance-Jones, N. Omelchenko, A. Bailis, S. Lynch, and K. Sharma
Hoxd10 induction and regionalization in the developing lumbosacral spinal cord
Development, June 15, 2001; 128(12): 2255 - 2268.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 1999