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Journal of Histochemistry and Cytochemistry, Vol. 47, 889-894, July 1999, Copyright © 1999, The Histochemical Society, Inc.

ARTICLE

Presence of H Type 3/4 Chains of ABO Histo-blood Group System in Serous Cells of Human Submandibular Gland and Regulation of Their Expression by the Secretor Gene (FUT2)

Yuhua Liua, Noboru Fujitania, Yoshiro Kodaa, Mikiko Soejimaa, and Hiroshi Kimuraa
a Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Kurume, Japan

Correspondence to: Hiroshi Kimura, Dept. of Forensic Medicine, Kurume Univ. School of Medicine, Kurume 830-0011, Japan.

We have investigated by immunochemistry the distribution of H Type 3/4 chains of the ABO histo-blood group system in human submandibular gland using a monoclonal anti-H MBr1 antibody specific for H Type 3/4 chains, and have found the expression of H Type 3/4 chains was mainly in the serous cells. Serous cells from secretors were stained by MBr1 but not by anti-A and anti-B antibodies, whereas serous cells from nonsecretors exhibited a negative reaction with MBr1. Mucous cells were not stained by MBr1. Only a few striated duct cells showed a weak reaction with anti-H MBr1. These results suggested that the H Type 3/4 chains were distributed predominantly in the serous cells of the human submandibular gland and that secretor Type {alpha}(1,2)fucosyltransferase (Se enzyme) controlled the synthesis of H Type 3/4 chains in vivo. Saliva also contained H Type 3/4 chains, which were controlled by the secretor gene (FUT2). The differences in the distributions of H Type 1, H Type 2, and H Type 3/4 chains of the ABO histo blood group system in the submandibular gland are discussed. (J Histochem Cytochem 47:889–894, 1999)

Key Words: ABO, MBr1, H type 3 chain, H type 4 chain, secretor gene (FUT2), submandibular gland


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