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Journal of Histochemistry and Cytochemistry, Vol. 48, 147-152, January 2000, Copyright © 2000, The Histochemical Society, Inc.

BRIEF REPORT

Localization of Monoamine Oxidase A and B in Human Pancreas, Thyroid, and Adrenal Glands

Manuel J. Rodrígueza, Josep Sauraa, Cheryl C. Finchb, Nicole Mahya, and Ellen E. Billettb
a Unitat de Bioquímica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
b Department of Life Sciences, Faculty of Science and Mathematics, The Nottingham Trent University, Nottingham, United Kingdom

Correspondence to: Nicole Mahy, Unitat de Bioquímica, Facultat de Medicina, U.B., C/ Casanova 143, E-08036 Barcelona, Spain.

We studied monoamine oxidase (MAO) A and B localization in human pancreas, thyroid gland, and adrenal gland by immunohistochemistry. The primary antibodies used were mouse monoclonal anti-human MAO-A (6G11/E1) and anti-human MAO-B (3F12/G10/2E3). Samples were obtained from six routine autopsy cases and fixed in 2% paraformaldehyde. Exocrine pancreas showed a widespread distribution of MAO-A, whereas MAO-B was present only in centroacinar cells and epithelial cells of pancreatic ducts. In endocrine pancreas, MAO-A was observed in around 50% of islet cells, whereas MAO-B was less abundant and was restricted to the periphery of islets. Thyroid gland showed strong MAO-A immunoreactivity in all cell types and was MAO-B-negative. In adrenal gland, the capsule displayed MAO-A but not MAO-B immunoreactivity, whereas the cortex showed widespread MAO-A staining but was MAO-B-negative in interstitial cells. Finally, in the medulla only a few scattered cells showed either MAO-A or MAO-B immunoreactivity. To our knowledge, these data represent the first study of the cellular distribution of MAO-A and MAO-B in the three human tissues included. (J Histochem Cytochem 48:147–151, 2000)

Key Words: monoamine oxidases (MAOs), pancreas, thyroid gland, adrenal gland, human, immunohistochemistry


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