Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lögdberg, L. E.
Right arrow Articles by Badve, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lögdberg, L. E.
Right arrow Articles by Badve, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry, Vol. 48, 1545-1552, November 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Tissue Distribution of the Lipocalin Alpha-1 Microglobulin in the Developing Human Fetus

Lennart E. Lögdberga, Bo Åkerströmb, and Sunil Badvea
a Department of Pathology, Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, New York
b Section for Molecular Signaling, Department of Cell and Molecular Biology, University of Lund, Lund, Sweden

Correspondence to: Lennart E. Lögdberg, Laboratory of Stem Cell Biology, Lindsay F. Kimball Research Inst., New York Blood Center, 310 East 67th Street, New York, NY 10021. E-mail: Logdberg@nybc.org or Lindalennart@msn.com

Alpha-1 microglobulin ({alpha}1m), a lipocalin, is an evolutionarily conserved immunomodulatory plasma protein. In all species studied, {alpha}1m is synthesized by hepatocytes and catabolized in the renal proximal tubular cells. {alpha}1m deficiency has not been reported in any species, suggesting that its absence is lethal and indicating an important physiological role for this protein To clarify its functional role, tissue distribution studies are crucial. Such studies in humans have been restricted largely to adult fresh/frozen tissue. Formalin-fixed, paraffin-embedded multi-organ block tissue from aborted fetuses (gestational age range 7–22 weeks) was immunohistochemically examined for {alpha}1m reactivity. Moderate to strong reactivity was seen at all ages in hepatocytes, renal proximal tubule cells, and a subset of pancreatic islet cells. Muscle (cardiac, skeletal, or smooth), adrenal cortex, a scattered subset of intestinal mucosal cells, tips of small intestinal villi, and Leydig cells showed weaker and/or variable levels of reactivity. Connective tissue stained with variable location and intensity. The following cells/sites were consistently negative: thymus, spleen, hematopoietic cells, lung parenchyma, glomeruli, exocrine pancreas, epidermis, cartilage/bone, ovary, seminiferous tubules, epididymis, thyroid, and parathyroid. The results underscore the dominant role of liver and kidney in fetal {alpha}1m metabolism and provide a framework for understanding the functional role of this immunoregulatory protein.

(J Histochem Cytochem 48:1545–1552, 2000)

Key Words: alpha-1-microglobulin, fetal, tissue distribution, lipocalin


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
B. Akerstrom, G. J. Maghzal, C. C. Winterbourn, and A. J. Kettle
The Lipocalin {alpha}1-Microglobulin Has Radical Scavenging Activity
J. Biol. Chem., October 26, 2007; 282(43): 31493 - 31503.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
P. C. Abad, J. Lewis, I. S. Mian, D. W. Knowles, J. Sturgis, S. Badve, J. Xie, and S. A. Lelievre
NuMA Influences Higher Order Chromatin Organization in Human Mammary Epithelium
Mol. Biol. Cell, February 1, 2007; 18(2): 348 - 361.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
S. Badve, C. Deshpande, Z. Hua, and L. Logdberg
Expression of Invariant Chain (CD 74) and Major Histocompatibility Complex (MHC) Class II Antigens in the Human Fetus
J. Histochem. Cytochem., April 1, 2002; 50(4): 473 - 482.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2000