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Journal of Histochemistry and Cytochemistry, Vol. 48, 1649-1656, December 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Distribution of H Type 1–4 Chains of the ABO(H) System in Different Cell Types of Human Respiratory Epithelium

Noboru Fujitania,b, Yuhua Liua, Torahiko Okamuraa, and Hiroshi Kimuraa
a Department of Forensic Medicine and Human Genetics, Faculty of Science, Okayama University of Science, Okayama, Japan
b Kurume University School of Medicine, Kurume, Japan, and Department of Biochemistry, Faculty of Science, Okayama University of Science, Okayama, Japan

Correspondence to: Hiroshi Kimura, Dept. of Forensic Medicine, Kurume U. School of Medicine, Kurume 830-0011, Japan. E-mail: hkimura@med.kurume-u.ac.jp

We used three anti-H monoclonal antibodies (MAbs) specific for H Type 1, H Type 2, and H Type 3/4 antigens to investigate the distribution of H Type 1–H Type 4 chains of the ABO(H) histo-blood group in the human respiratory system. Strong staining of H Type 1 chain and weak staining of H Type 2 chain were observed in mucous cells of submucosal glands of bronchial epithelium, which were dependent on the secretor status. No H Type 3/4 chains were detected in mucous cells. Serous cells of submucosal glands of respiratory system showed no staining by three anti-H antibodies. H Type 1 and H Type 3/4 antigens were detected heterogeneously in apical surfaces of bronchial epithelium from secretors but not from nonsecretors. In contrast, basal cells of bronchial epithelium expressed H Type 2 irrespective of the secretor status, probably regulated by the H gene. Some alveolar Type II cells contained only H Types 3/4, which were dependent on the secretor status, whereas alveolar Type I cells had no H antigens. Our results indicated that different cell types in respiratory epithelium expressed different types of carbohydrate chains of histo-blood group antigens under the control of the H or the Se gene. (J Histochem Cytochem 48:1649–1655, 2000)

Key Words: ABO, H antigen, respiratory epithelium, fucosyltransferase, secretor


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