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Journal of Histochemistry and Cytochemistry, Vol. 48, 259-266, February 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Glial Fibrillary Acidic Protein (GFAP)-like Immunoreactivity in Rat Endocrine Pancreas

Marì Regolia, Daniela Oraziolia, Renato Gerlia, and Eugenio Bertellia
a Department of Biomedical Sciences, University of Siena, Siena, Italy

Correspondence to: Eugenio Bertelli, Dept. of Biomedical Sciences, University of Siena, Via Aldo Moro, I-53100 Siena, Italy.

The study of intermediate filament expression in the pancreatic epithelium has been previously focused almost exclusively on cytokeratins. Transient vimentin immunoreactivity has also been detected in duct cells of rat fetal pancreas. Here we report that, in rat pancreas, intense GFAP-like immunoreactivity is detectable in a subpopulation of endocrine cells located in the periphery of the islet of Langerhans. In addition, staining appeared to be preferentially localized to the apical pole of the cells. Two different polyclonal antibodies were employed in this study, with analogous results. Staining of consecutive sections with anti-GFAP, anti-glucagon, and anti-somatostatin antibodies demonstrates that GFAP-like immunoreactivity is present in glucagon-secreting cells. The relevance of this finding is discussed. (J Histochem Cytochem 48:259–265, 2000)

Key Words: intermediate filaments, GFAP, pancreas, glucagon cells, immunocytochemistry, rat


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