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Journal of Histochemistry and Cytochemistry, Vol. 48, 277-284, February 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Epithelial Dlx-2 Homeogene Expression and Cementogenesis

Frédéric Lézota, Jean-Luc Davideaua, Bethan Thomasb, Paul Sharpeb, Nadine Foresta, and Ariane Berdala
a Laboratoire de Biologie-Odontologie, EA 2380, Institut Biomédical des Cordeliers, Université Paris VII, Paris, France
b Department of Craniofacial Development, Kings College, Guy's Hospital, London, United Kingdom

Correspondence to: Frédéric Lézot, Laboratoire de Biologie Odontologie, E2380, Université Paris VII, Institut Biomédical des Cordeliers, 15-21 rue de l'Ecole de Médecine, 75006 Paris, France.

The Dlx-2 (distal-less gene) homeoprotein transcription factor controls early tooth development but has not been studied during the late stages of biomineralization. Transgenic mice containing a Dlx-2/LacZ reporter construct were used to map the Dlx-2 expression pattern in cementoblasts, the dental cells most closely related to bone cells and therefore suggested to be uniquely positioned osteoblasts. During initial root formation, marked expression of Dlx-2 was evident in molar and incisor root epithelium, whereas dental papilla and follicle were negative. Dlx-2 was expressed in this epithelium from the apical loop to the area of its disruption. During acellular cementum formation in both incisors and molars, Dlx-2 expression was observed in the majority of differentiated cementoblasts from the apical region to the erupting zones. During cellular cementum formation, the presence of which characterizes growth-limited molars, Dlx-2 expression was restricted to the innermost cementoblasts and entrapped cementocytes. These data further support the hypothesis of a complex origin and fate of cementum-forming cells, as previously suggested by the expression patterns of a set of mesenchymal and epithelial markers, notably ameloblastin as shown here. Dlx-2 expression might constitute a landmark of cementoblast subpopulations of epithelial origin. (J Histochem Cytochem 48:277–283, 2000)

Key Words: Dlx-2, homeobox gene, tooth, root formation


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