Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lézot, F.
Right arrow Articles by Berdal, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lézot, F.
Right arrow Articles by Berdal, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry, Vol. 48, 277-284, February 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Epithelial Dlx-2 Homeogene Expression and Cementogenesis

Frédéric Lézota, Jean-Luc Davideaua, Bethan Thomasb, Paul Sharpeb, Nadine Foresta, and Ariane Berdala
a Laboratoire de Biologie-Odontologie, EA 2380, Institut Biomédical des Cordeliers, Université Paris VII, Paris, France
b Department of Craniofacial Development, Kings College, Guy's Hospital, London, United Kingdom

Correspondence to: Frédéric Lézot, Laboratoire de Biologie Odontologie, E2380, Université Paris VII, Institut Biomédical des Cordeliers, 15-21 rue de l'Ecole de Médecine, 75006 Paris, France.

The Dlx-2 (distal-less gene) homeoprotein transcription factor controls early tooth development but has not been studied during the late stages of biomineralization. Transgenic mice containing a Dlx-2/LacZ reporter construct were used to map the Dlx-2 expression pattern in cementoblasts, the dental cells most closely related to bone cells and therefore suggested to be uniquely positioned osteoblasts. During initial root formation, marked expression of Dlx-2 was evident in molar and incisor root epithelium, whereas dental papilla and follicle were negative. Dlx-2 was expressed in this epithelium from the apical loop to the area of its disruption. During acellular cementum formation in both incisors and molars, Dlx-2 expression was observed in the majority of differentiated cementoblasts from the apical region to the erupting zones. During cellular cementum formation, the presence of which characterizes growth-limited molars, Dlx-2 expression was restricted to the innermost cementoblasts and entrapped cementocytes. These data further support the hypothesis of a complex origin and fate of cementum-forming cells, as previously suggested by the expression patterns of a set of mesenchymal and epithelial markers, notably ameloblastin as shown here. Dlx-2 expression might constitute a landmark of cementoblast subpopulations of epithelial origin. (J Histochem Cytochem 48:277–283, 2000)

Key Words: Dlx-2, homeobox gene, tooth, root formation


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
A. Hirata and H. Nakamura
Localization of Perlecan and Heparanase in Hertwig's Epithelial Root Sheath During Root Formation in Mouse Molars
J. Histochem. Cytochem., October 1, 2006; 54(10): 1105 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
D.D. Bosshardt
Are Cementoblasts a Subpopulation of Osteoblasts or a Unique Phenotype?
J. Dent. Res., May 1, 2005; 84(5): 390 - 406.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
H. Yamamoto, S.-W. Cho, E.-J. Kim, J.-Y. Kim, N. Fujiwara, and H.-S. Jung
Developmental Properties of the Hertwig's Epithelial Root Sheath in Mice
J. Dent. Res., September 1, 2004; 83(9): 688 - 692.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
J.R. Smid, J.E. Rowland, W.G. Young, T.J. Daley, K.T. Coschigano, J.J. Kopchick, and M.J. Waters
Mouse Cellular Cementum is Highly Dependent on Growth Hormone Status
J. Dent. Res., January 1, 2004; 83(1): 35 - 39.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2000