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Journal of Histochemistry and Cytochemistry, Vol. 48, 445-458, April 2000, Copyright © 2000, The Histochemical Society, Inc.

REVIEW

Contributions of Immunohistochemistry and In Situ Hybridization to the Functional Analysis of Pituitary Adenomas

R. Yoshiyuki Osamuraa, Shigeyuki Taharab, Reiko Kurotania, Naoko Sannob, Akira Matsunoc, and Akira Teramotob
a Department of Pathology, Tokai University School of Medicine, Boseidai Isehara-city, Kanagawa, Japan
b Department of Neurosurgery, Nippon Medical School, Tokyo, Japan
c Department of Neurosurgery, Teikyo University Ichihara Hospital, Chiba, Japan

Correspondence to: R. Yoshiyuki Osamura, Dept. of Pathology, Tokai Univ. School of Medicine, Boseidai Isehara-city, Kanagawa 259-1193, Japan.

Immunohistochemistry (IHC) and recently in situ hybridization (ISH) have elucidated various aspects of human pituitary adenomas, i.e., functional differentiation and classification, transcription factors and mechanism of hormone production, regulation of hormone secretion, and processing of prohormones. Recently, the use of tyramide (catalyzed signal amplification; TSA or CSA) and RT-PCR has been effective for detection of trivial amount of proteins (peptides) and mRNA, respectively. Immunomolecular histochemistry is expected to further clarify the function and biology of human pituitary adenomas. (J Histochem Cytochem 48:445–458, 2000)

Key Words: pituitary adenoma, immunohistochemistry, in situ hybridization, transcription factor, nuclear receptor, steroid receptor, pituitary hormone, hypothalamic hormone


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