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Journal of Histochemistry and Cytochemistry, Vol. 48, 557-568, April 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Intercellular Adhesion Molecule-1 and Hair Follicle Regression

Sven Müller–Rövera,b, Silvia Bulfone–Pausc, Bori Handjiskib, Pia Welkerb, John P. Sundbergd, Ian A. McKaya, Vladimir A. Botchkarevb, and Ralf Pausb,e
a Centre for Cutaneous Research, University of London, London, United Kingdon
b Department of Dermatology, Charité, Humboldt University, Berlin, Germany
c Institute of Immunology, Free University, Berlin, Germany
d The Jackson Laboratory, Bar Harbor, Maine
e Department of Dermatology, Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Hamburg, Germany

Correspondence to: Sven Müller–Röver, Centre for Cutaneous Research, St Bartholomew's and the Royal London School of Dentistry, QMW, 2 Newark Street, London E1 2AT, UK.

Although the intercellular adhesion molecule-1 (ICAM-1) is recognized for its pivotal role in inflammation and immune responses, its role in developmental systems, such as the cyclic growth (anagen) and regression (catagen) of the hair follicle, remains to be explored. Here we demonstrate that ICAM-1 expression in murine skin is even more widespread and more developmentally regulated than was previously believed. In addition to endothelial cells, selected epidermal and follicular keratinocyte subpopulations, as well as interfollicular fibroblasts, express ICAM-1. Murine hair follicles express ICAM-1 only late during morphogenesis. Thereafter, morphologically identical follicles markedly differ in their ICAM-1 expression patterns, which become strikingly hair cycle-dependent in both intra- and extrafollicular skin compartments. Minimal ICAM-1 and leukocyte function-associated (LFA-1) protein and mRNA expression is observed during early anagen and maximal expression during late anagen and catagen. Keratinocytes of the distal outer root sheath, fibroblasts of the perifollicular connective tissue sheath, and perifollicular blood vessels exhibit maximal ICAM-1 immunoreactivity during catagen, which corresponds to changes of LFA-1 expression on perifollicular macrophages. Finally, ICAM-1-deficient mice display significant catagen acceleration compared to wild-type controls. Therefore, ICAM-1 upregulation is not limited to pathological situations but is also important for skin and hair follicle remodeling. Collectively, this suggests a new and apparently nonimmunological function for ICAM-1-related signaling in cutaneous biology. (J Histochem Cytochem 48:557–568, 2000)

Key Words: depilation, ICAM-1-deficient mice, LFA-1, connective tissue sheath, hair cycle, catagen, mouse mutant, skin, adhesion receptor, adhesion molecules


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