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Journal of Histochemistry and Cytochemistry, Vol. 48, 603-612, May 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Differential Expression of Peroxisome Proliferator-activated Receptors (PPARs) in the Developing Human Fetal Digestive Tract

Cécile Huina, Lina Corriveaub, Arnaud Bianchia, Jean Marie Kellera, Philippe Colleta, Pascaline Krémarik-Bouillauda, Lionel Domenjouda, Philippe Bécuwea, Hervé Schohna, Daniel Ménardb, and Michel Dauçaa
a Laboratoire de Biologie Cellulaire du Développement, EA 2402 "Proliférateurs de Peroxysomes," Faculté des Sciences, Vandoeuvre-les-Nancy, France
b Groupe CRM de Recherche sur le Développement Fonctionnel et la Physiopathologie du Tube Digestif, Département Anatomie et Biologie Cellulaire, Faculté de Médecine, Sherbrooke, Québec, Canada

Correspondence to: Cécile Huin, Laboratoire de Biologie cellulaire du Développement, UPRES 2402 “Proliférateurs de Peroxysomes,” Faculté des Sciences, BP 239, 54506 Vandoeuvre-les-Nancy Cedex, France.

We investigated the spatiotemporal distributions of the different peroxisome proliferator-activated receptor (PPAR) isotypes ({alpha}, ß, and {gamma}) during development (Week 7 to Week 22 of gestation) of the human fetal digestive tract by immunohistochemistry using specific polyclonal antibodies. The PPAR subtypes, including PPAR{gamma}, are expressed as early as 7 weeks of development in cell types of endodermal and mesodermal origin. The presence of PPAR{gamma} was also found by Western blotting and nuclease-S1 protection assay, confirming that this subtype is not adipocyte-specific. PPAR{alpha}, PPARß, and PPAR{gamma} exhibit different patterns of expression during morphogenesis of the digestive tract. Whatever the stage and the gut region (except the stomach) examined, PPAR{gamma} is expressed at a high level, suggesting some fundamental role for this receptor in development and/or physiology of the human digestive tract. (J Histochem Cytochem 48:603–611, 2000)

Key Words: PPARs, development, differentiation, fetus, digestive tract


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