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Journal of Histochemistry and Cytochemistry, Vol. 48, 915-922, July 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Placental Expression and Chromosomal Localization of the Human Gcm 1 Gene

Brahim Nait–Oumesmara, Alan B. Coppermanb, and Robert A. Lazzarinia
a Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York City, New York
b Department of Obstetrics and Gynecology, Mount Sinai School of Medicine, New York City, New York

Correspondence to: Robert A. Lazzarini, Mount School of Medicine, Dept. of Biochemistry and Molecular Biology, Box 1020, 1 Gustave Levy Place, New York, NY 10029. E-mail: robert.lazzarini@mssm.edu

Although gcm was first recognized for its role in specifying glial cell fate in Drosophila melanogaster, its mammalian counterparts are expressed predominantly in non-neural tissues. Here we demonstrate expression of the mouse and human GCM 1 proteins in placenta. We have prepared a highly specific antibody that recognizes the GCM 1 protein and have used it to assess the temporal and spatial expression profile of the protein. In both mouse and human placenta, the protein is associated with cells that are involved with exchange between maternal and fetal blood supplies: the labyrinthine cells of the mouse placenta and the syncytio- and cytotrophoblasts of the human placenta. Using the full-length hGcm 1 cDNA as a probe, we have mapped the gene on human chromosome 6p12 by fluorescent in situ hybridization. (J Histochem Cytochem 48:915–922, 2000)

Key Words: glial cell missing, human placenta, trophoblast development


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