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Journal of Histochemistry and Cytochemistry, Vol. 48, 999-1010, July 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Cellular Localization of Gene Expression for Progranulin

Rachael Daniela, Zhiheng Hea, K. Paige Carmichaelb, Jaroslava Halperb, and Andrew Batemana
a Endocrine Laboratory, Royal Victoria Hospital and Division of Experimental Medicine, McGill University, Montréal, Québec, Canada,
b Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia

Correspondence to: Andrew Bateman, Room L.2.05, Endocrine Laboratory, Royal Victoria Hospital, 687 Pine Ave West, Montréal, Québec H3A 1A1, Canada. E-mail: bateman@rvhmed.lan.mcgill.ca

Granulins, also called epithelins, are 6-kD peptides with growth modulatory effects on a variety of cells. The granulin/epithelin precursor supports tumorigenesis in appropriate cell models and is the only growth factor able to overcome the cell cycle block that occurs in murine fibroblasts after deletion of a functional IGF-1 receptor. However, little is known of the role of granulin/epithelin gene products in vivo. To understand the physiological role of granulins it is essential to know the cell types and conditions in which it is expressed. We examined granulin/epithelin gene expression in adult rodents by in situ hybridization. The granulin/epithelin precursor is constitutively expressed in a number of epithelia, particularly in the skin, GI tract, and reproductive system. Other epithelia express the gene less strongly. Progranulin is expressed in immune cells in vivo and in specific neurons in the brain, including Purkinje cells, pyramidal cells of the hippocampus, and some cerebral cortical neurons. Little expression was detected in muscle cell, connective tissue, or endothelium. Cumulatively, these results define the basal gene expression of a new growth factor system and suggest that the progranulin/epithelin gene is multifunctional, with important constitutive roles in epithelial homeostasis, reproductive, immunological, and neuronal function. (J Histochem Cytochem 48:999–1009, 2000)

Key Words: progranulin, epithelin, acrogranin, PCDGF, TGFe, growth factor


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