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Journal of Histochemistry and Cytochemistry, Vol. 48, 1203-1214, September 2000, Copyright © 2000, The Histochemical Society, Inc.

ARTICLE

Gene Expression of Receptors for IL-6, LIF, and CNTF in Regenerating Skeletal Muscles

Katsuya Kamia, Yoshihiro Morikawac, Masashi Sekimotob, and Emiko Senbac
a Department of Health Science, Osaka University of Health and Sport Sciences,Osaka, Japan
b Division of Immunoregulation, Institute of Genetic Medicine, Hokkaido University, Hokkaido, Japan
c Department of Anatomy & Neurobiology, Wakayama Medical College, Wakayama, Japan

Correspondence to: Katsuya Kami, Dept. of Health Science, Osaka Univ. of Health and Sport Sciences, Noda 1558-1, Kumatori-cho, Sennan-gun, Osaka 590-0496, Japan. E-mail: kami@ouhs.ac.jp

The biological actions of interleukin-6 (IL-6), leukemia inhibitory factor (LIF), and ciliary neurotrophic factor (CNTF) are mediated via respective functional receptor complexes consisting of a common signal-transducing component, gp130, and other specific receptor components, IL-6 receptor {alpha} (IL-6R), LIF receptor ß (LIFR), and CNTF receptor {alpha} (CNTFR). IL-6, LIF, and CNTF are implicated in skeletal muscle regeneration. However, the cell populations that express these receptor components in regenerating muscles are unknown. Using in situ hybridization histochemistry, we examined spatiotemporal expression patterns of gp130, IL-6R, LIFR, and CNTFR mRNAs in regenerating muscles after muscle contusion. At the early stages of regeneration (from 3 hr to Day 2 post contusion), significant signals for gp130 and LIFR mRNAs were detected in myonuclei and/or nuclei of muscle precursor cells (mpcs) and in mononuclear cells located in extracellular spaces between myofibers after muscle contusion, but IL-6R mRNA was expressed only in mononuclear cells. At Day 7 post contusion, signals for gp130, LIFR, and IL-6R mRNAs were not detected in newly formed myotubes, whereas the CNTFR mRNA level was upregulated in myotubes. These findings suggest that the upregulation of receptor subunits in distinct cell populations plays an important role in the effective regeneration of both myofibers and motor neurons. (J Histochem Cytochem 48:1203–1213, 2000)

Key Words: leukemia inhibitory factor, receptor ß, ciliary neurotrophic factor, receptor {alpha}, interleukin-6 receptor {alpha}, gp130, muscle regeneration


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