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Journal of Histochemistry and Cytochemistry, Vol. 49, 1245-1252, October 2001, Copyright © 2001, The Histochemical Society, Inc.

ARTICLE

Reduced Expression of Activin A in Focal Lymphoid Agglomerates Within Nasal Polyps

Tsipi Shohama, Eitan Yanivb, Rumelia Korenb, Rivka Galb, Reshmi Parameswarana, Arkadi Kravitzb, Henry Geronb, Dana Markovitzb, Marina Lantzkib, and Dov Ziporia
a Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
b Rabin Medical Center, Petach Tikva, Israel

Correspondence to: Dov Zipori, Dept. of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. E-mail: lczipori@wicc.weizmann.ac.il

It has been previously reported that activin A, a homodimer of the ßA inhibin subunit, is secreted by stromal cells from mouse bone marrow and causes apoptotic death of mouse plasmacytoma tumor cells. Recent in vitro studies have also implicated this cytokine in the suppression of normal B-cell lymphopoiesis. In this study we examined the occurrence of activin A in nasal polyp tissues that present a combination of epithelium, mesenchyme, and vascular endothelium, with frequent massive hemopoietic infiltration. Anti-ßA-chain antibodies strongly stained epithelial mucous glands and some endothelial cells, and diffusely stained the polyp stroma. Normal adult conchae were similarly stained, whereas activin A was not detected prenatally by immunostaining of nasal tissues. Staining specificity was substantiated by ligand competition assays. Detailed examination of the inflammatory polyp infiltrate showed that activin A staining was reduced in sites of focal infiltration of B-lymphoid cells. It is therefore implied that local accumulation of a large number of B-cells is associated with relatively low activin A expression.

(J Histochem Cytochem 49:1245–1252, 2001)

Key Words: activin A, nasal polyps, B-lymphocytes, TGFß, stroma


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Stem Cells, November 1, 2002; 20(6): 493 - 500.
[Abstract] [Full Text] [PDF]



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