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Journal of Histochemistry and Cytochemistry, Vol. 49, 1325-1326, October 2001, Copyright © 2001, The Histochemical Society, Inc.

BRIEF REPORT

In Situ Hybridization Analysis of Preprotachykinin-A mRNA Levels in Young and Old Rats

P. Pompeia, R. Severinia, D. Pediconia, D. Martarellia, M. Massia, P. Fattorettib, and C. Bertoni–Freddarib
a Department of Pharmacological Sciences & Experimental Medicine, University of Camerino, Camerino, Italy
b Center for Surgical Research, Neurobiology of Aging Section, INRCA, Ancona, Italy

Correspondence to: P. Pompei, Dept. of Pharmacological Sciences & Experimental Medicine, University of Camerino, Camerino MC-62032, Italy. E-mail: pompei@cambio.unicam.it

Preprotachykinin-A (PPT-A) mRNA levels in discrete rat brain regions were examined. Analysis of silver grains revealed a 19.2% and 31.5% statistically significant decrease in PPT-A mRNA in the dorsal and ventral caudate putamen (d-CPu and v-CPu), respectively, a 30% lower expression of PPT-A mRNA in the bed nucleus of the stria terminalis (BNST), a 33.7% decrease in PPT-A mRNA in the habenula (Hb), and a 30% decrease of PPT-A mRNA levels in the posterodorsal part of the medial amygdala (MePD). Results show that aging of the CNS is associated with widespread changes in tachykinin gene expression, suggesting that alterations in the tachykinergic system may have implications in the physiopathology of the elderly. (J Histochem Cytochem 49:1325–1326, 2001)

Key Words: aging, PPT-A, in situ hybridization, substance P


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