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Journal of Histochemistry and Cytochemistry, Vol. 49, 209-218, February 2001, Copyright © 2001, The Histochemical Society, Inc.

ARTICLE

Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase

Noemí Andrésa, José Miguel Lizcanob, Manuel J. Rodrígueza, Manuel Romerab, Mercedes Unzetab, and Nicole Mahya
a Unitat de Bioquímica, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
b Departament de Bioquímica, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain

Correspondence to: Nicole Mahy, Unitat de Bioquímica, Facultat de Medicina, UB, C/Casanova, 143, Barcelona E-08036, Spain. E-mail: mahy@medicina.ub.es

Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines. To assess whether its physiological role in humans is restricted to oxidation, we used an immunohistochemical approach to examine the cellular localization of SSAO in human peripheral tissues (adrenal gland, duodenum, heart, kidney, lung, liver, pancreas, spleen, thyroid gland, and blood vessels) and also analyzed its subcellular localization. The results are in agreement with the specific activities also determined in the same samples and are discussed with reference to the tissue distribution of monoamine oxidase A and B. Together with the oxidative deamination of monoamines, SSAO cellular localization indicates that, in most human peripheral tissues, it might participate in the regulation of physiological processes via H2O2 generation. (J Histochem Cytochem 49:209–217, 2001)

Key Words: semicarbazide-sensitive amine, oxidase (SSAO), human peripheral tissues, immunohistochemistry, enzymology


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