Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Luca, A.
Right arrow Articles by Paggi, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Luca, A.
Right arrow Articles by Paggi, M. G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry, Vol. 49, 685-692, June 2001, Copyright © 2001, The Histochemical Society, Inc.

ARTICLE

Pattern of Expression of Cyclin T1 in Human Tissues

Antonio De Lucaa, Patrizia Russoa, Anna Severinoa, Alfonso Baldia, Tullio Battistaa, Ivan Cavallottib, Luca De Lucab, Feliciano Baldic, Antonio Giordanod, and Marco G. Paggia
a Laboratory of Cell Metabolism and Pharmacokinetics, CRS, Regina Elena Cancer Institute, Rome, Italy
b Institute of Topographical Anatomy, School of Medicine, Second University of Naples, Naples, Italy
c Department of Biochemistry and Biophysics "F. Cedrangolo," Section of Anatomic Pathology, School of Medicine, Second University of Naples, Naples, Italy
d Departments of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania

Correspondence to: Marco G. Paggi, Laboratory for Cell Metabolism and Pharmacokinetics, Center for Experimental Research, Regina Elena Cancer Institute, Via delle Messi d'Oro, 156, 00158 Rome, Italy. E-mail: paggi@ifo.it

Cyclin T1 was recently identified, together with cdk9 (previously named PITALRE), as part of the TAK multiprotein complex, a co-factor targeted by the human immunodeficiency virus Type 1 (HIV-1) protein named Tat, suggesting a role for this complex in transcription elongation. Although studies on mRNA and protein expression have shown that cyclin T1 is ubiquitous in adult human tissues, no data have yet been reported regarding the expression of this protein in different cell lineages. Using a polyclonal antiserum raised against cyclin T1, we investigated the pattern of expression of this protein in adult human tissues by immunohistochemistry. Cyclin T1 was expressed ubiquitously, although different levels of expression were found in various organs. Some specialized tissues, such as blood, lymphoid tissues, and cells of connective tissue origin, showed high cyclin T1 expression. These specific expression patterns are only partially justified by some well-known specialized functions of cyclin T1 in certain cell types, such as its involvement in peripheral blood lymphocytes and monocyte differentiation. The high expression level found in other tissues suggests new possible roles for cyclin T1 in cell types other than those of lymphoid tissue. (J Histochem Cytochem 49:685–692)

Key Words: cyclin T1, cyclin T2, polyclonal antibody, immunohistochemistry, human tissues, keratinocytes


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
I. Iankova, R. K. Petersen, J.-S. Annicotte, C. Chavey, J. B. Hansen, I. Kratchmarova, D. Sarruf, M. Benkirane, K. Kristiansen, and L. Fajas
Peroxisome Proliferator-Activated Receptor {gamma} Recruits the Positive Transcription Elongation Factor b Complex to Activate Transcription and Promote Adipogenesis
Mol. Endocrinol., July 1, 2006; 20(7): 1494 - 1505.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
A. De Luca, A. Tosolini, P. Russo, A. Severino, A. Baldi, L. De Luca, I. Cavallotti, F. Baldi, A. Giordano, J. R. Testa, et al.
Cyclin T2A Gene Maps on Human Chromosome 2q21
J. Histochem. Cytochem., June 1, 2001; 49(6): 693 - 698.
[Abstract] [Full Text]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2001